Now showing items 1-15 of 15
Roda Noguera, Oriol (Date of defense: 2006-05-30)
El càncer de pàncrees és altament agressiu i representa la cinquena causa de mort al mon occidental. Anteriorment, en el nostre laboratori, vam identificar que el receptor tissular del plasminogen (tPA) hi està sobre-expressat ...
López Oreja, Irene (Date of defense: 2022-03-01)
Mutations in Splicing Factor 3b Subunit 1(SF3B1) are observed in 15% of patients with chronic lymphocytic leukemia (CLL) and are associated with worse disease prognosis. SF3B1 is involved in pre-mRNA splicing and is the ...
Morey Ramonell, Lluís (Date of defense: 2008-02-01)
En mamíferos, así como en plantas, mutaciones en AND helicasas/ATPasas del la família SNF2, no solo afectan a la estructura de la cromatina, sino que también afectan al patrón global de la metilación del ADN. Sugiriendo ...
Sparavier, Aleksandra (Date of defense: 2022-06-03)
Chromosomal translocation are large-scale genome rearrangements found in several cancers. They are formed when two (or more) non-homologous chromosomes interchange large parts as a result of erroneous DNA repair after ...
Fernández Ibarrondo, Lierni (Date of defense: 2024-04-05)
Las neoplasias mieloproliferativas Philadelphia-negativas son enfermedades clonales que se originan en las células madre hematopoyéticas, ocasionadas por la adquisición de mutaciones driver que afectan a la vía JAK/STAT. ...
Vafeiadi, Marina (Date of defense: 2014-02-26)
Introduction: Persistent Organic Pollutants (POPs) include a wide range of synthetic chemical substances that are ubiquitous in the environment and are identified as endocrine disrupting chemicals (EDCs) which can alter ...
Rovira Clusellas, Meritxell (Date of defense: 2007-01-31)
Las patologías más importantes del páncreas exocrino, como la pancreatitis crónica (PC) o el cáncer de páncreas, representan un gran problema de salud pública en Europa. En la PC, el tejido acinar es substituido por complejos ...
Sentís Carreras, Inés (Date of defense: 2021-01-22)
Acute lymphoblastic leukemia (ALL) is a blood cancer characterized by a high proliferation and maturation arrest of the lymphoid precursors which can either be from B or T-cell lineage. In adult patients, this type of ...
García Gisbert, Nieves (Date of defense: 2022-03-04)
Myeloid malignancies are clonal diseases originated in myeloid hematopoietic stem cells that are frequently initiated by somatic mutations. The detection of genetic alterations has considerably improved the diagnostic ...
Bigorra López, Laura (Date of defense: 2022-04-08)
The complete blood count (CBC) is one of the most commonly performed test due to its clinical utility, versatility and safety. Thus, there are well established consensus rules to review a CBC through the peripheral blood ...
Uribesalgo Micàs, Iris (Date of defense: 2010-11-24)
The c-Myc transcription factor is a key player in cell homeostasis, being commonly deregulated in human carcinogenesis. In this PhD thesis we have addressed the question how regulatory mechanisms restrain the oncogenic ...
Villa, Raffaella (Date of defense: 2007-12-10)
Mi trabajo ha estado enfocado en la implicación de los diferentes mecanismos epigenéticos de PML-RARa en la inducción de la leucemia promielocítica aguda (APL).<br/>En particular yo estudié el rol de MBD1, un miembro de ...
Espelt Hernández, Albert (Date of defense: 2011-11-28)
Type 2 diabetes mellitus (T2DM) has become a major health problem worldwide. The St. Vincent declaration emphasized the urgent need to improve the epidemiological knowledge of this disease in Europe. Within Europe, research ...
Bajew, Simon (Date of defense: 2022-04-12)
Alternative splicing is a post-transcriptional process that allows the generation of multiple transcript and protein isoforms from a single gene by differential processing of exons and introns. This Thesis focuses on ...
García Montolío, Marc (Date of defense: 2019-10-31)
Polycomb group (PcG) of proteins are a group of highly conserved epigenetic regulators involved in many biological functions such as embryonic development, stem cell self-renewal, cell proliferation, and cancer. PHD finger ...