Meyer, Markus (Date of defense: 2010-03-26)
The informational content of 3' splice sites is low and the mechanisms whereby they are selected are not clear. Here we enunciate a set of rules that govern their selection. For many introns, secondary ...
Rodríguez-Morató, Jose (Date of defense: 2016-06-20)
Hydroxytyrosol [2-(3,4-dihydroxyphenyl)ethanol], a potent bioactive molecule mainly present in virgin olive oil and to a lower extent in wine, is also a by-product of dopamine metabolism. In a previous ...
Jagiełło, Bogumiła (Date of defense: 2018-12-05)
La localització de molècules d'ARNm permet regular la síntesi de proteïnes localment i temporalment i això és vital per molts processos cel·lular fonamentals. A Oligodendròcits el transport de l'ARNm ...
Bonet Martínez, Jaume (Date of defense: 2015-01-30)
Proteins are the basic functional and structural blocks of life. Knowledge of their structure and function is key to understand how it works. Lately, the gap between new discovered proteins and ...
Aivio, Suvi Marjaana (Date of defense: 2014-10-10)
Mitochondrial dysfunction arising from aberrant mitochondrial nucleic acid homeostasis has been associated with various pathologies. In this thesis, we aim to characterize a putative mitochondrial ...
García-García, Javier (Date of defense: 2015-01-23)
The use of protein-protein interaction networks has become crucial due to the emergence of systems biology. The completeness and quality of networks, crucial to understand the biochemical mechanisms ...
Gómez Escoda, Blanca (Date of defense: 2010-11-26)
When DNA replication is challenged, cells activate a DNA synthesis checkpoint blocking cell cycle progression until they are able to overcome the replication defects. In fission yeast, Cds1 is the ...
Sallander, Eva Jessica (Date of defense: 2011-07-04)
Una de las principales cuestiones en farmacología molecular de los GPCR es entender los mecanismos estructurales de las siete hélices transmembrana (TM) que se producen para estabilizar ya sea Rg o los ...
Onrubia Ibáñez, Miriam (Date of defense: 2012-04-03)
Secondary metabolism in plants produces numerous compounds with wide-ranging activities, including the antineoplastic compound taxol and related taxanes. The biotechnological production of taxol has so ...
Wyatt, Christopher Douglas Robert (Date of defense: 2019-06-19)
The transition from maternal to embryonic control is a crucial time in an organism’s life cycle, with an overhaul of the epigenetic marks, targeted mRNA degradation and the initiation of transcription. ...