Kuderna, Lukas (Date of defense: 2020-01-24)
Genomic analyses are at the center of contemporary biology. These studies heavily rely on reference genome assemblies, yet those are typically highly fragmented. Having accurate representations of complex ...
Antonelli, Maria Carla (Date of defense: 2021-03-24)
During the last decades the non-coding portion of the genome became subject of intense research due to its contribution to the complexity of biological and pathological processes. CircRNAs are a class ...
López Blanch, Laura (Date of defense: 2021-04-30)
Neural microexons are the most conserved type of alternative splicing, suggesting a strong functional relevance. Consistently, mutation of their master regulators leads to dramatic neurodevelopmental ...
Borao Arriazu, Sonia (Date of defense: 2022-07-22)
Schizosaccharomyces pombe initiates sexual development under nitrogen starvation, changing the transcription patterns of many genes to allow sexual differentiation. MBF transcription factor recognize ...
Farré Ramon, Xavier (Date of defense: 2022-07-01)
Ageing is a very complex phenotype that has been widely studied, but is still largely unknown. Most of the studies focus on a single species, or on performing genome wide association studies in human ...
Sodaei, Reza (Date of defense: 2020-05-22)
How do genomes generate different tissues, behaviours, individuals or species? We try to identify parts of the human transcriptome that we found only in a tissue. Then, we focus on inter-individual ...
Meseguer Donlo, Alberto (Date of defense: 2021-07-02)
Las células de nuestro cuerpo son capaces de tener comportamientos y morfologías completamente diferentes, pese a contener el mismo material genético. Entre los mecanismos que permiten esta diversidad ...
Elosua-Bayés, Marc (Date of defense: 2023-06-08)
Understanding multicellular organisms depends on the advent of technologies capable of delivering unprecedented levels of resolution. With new technologies come novel data modalities, which require ...
Karamtzioti, Paraskevi (Date of defense: 2021-02-01)
This thesis aimed to characterize the tubulin PTM profile of human oocytes and spermatozoa. Tubulin rich structures play critical roles in the cellular behavior of human gametes. Mutations in tubulin ...
Palmada Flores, Marc (Date of defense: 2023-11-27)
Modern biology relies on genomic references to perform analyses in most studies. High-quality de novo genome assemblies are key to having references containing all the genomic content of a species. ...