Massoni Badosa, Ramon (Date of defense: 2023-03-13)
Specialization and plasticity are hallmarks of immune cells. Thus, charting their heterogeneity is crucial to understand their function and role in diseases. In this setting, single-cell RNA-sequencing ...
Platania, Leonardo (Date of defense: 2023-10-11)
The South Pacific is an intriguing region for studying evolutionary biology, presenting an exceptional diversity and complex geological and environmental characteristics. New Caledonia, in particular, ...
Borsari, Beatrice (Date of defense: 2021-03-26)
We have monitored the transcriptome and the epigenome of human pre-B cells transdifferentiating into macrophages. Analysis of these data provides a general framework to understand the relationship between ...
Mitsi, Konstantina (Date of defense: 2021-05-28)
Los organismos eucariotas abarcan una diversidad inmensa de formas, tamaños y estilos de vida. Sin embargo, abordar la verdadera amplitud de esa diversidad es una tarea laboriosa. Durante las últimas ...
Mugianesi, Francesca (Date of defense: 2022-06-02)
Gene expression, epigenetic states and topological conformation are three fundamental aspects of genome organization that are tightly regulated in space and time. Epigenetic states, protein occupancy ...
Balart i García, Pau (Date of defense: 2023-02-24)
Under very specific pressures, evolution turns extremely convergent, to the extent that distantly-related organisms show highly similar morphological, physiological and behavioral adaptations. Life into ...
Martínez Fernández, Carmen (Date of defense: 2021-03-12)
Model organisms and gene-editing strategies are fundamental to address a variety of scientific questions from basic science to biomedical research. Here, we reinforced the use of two powerful tools, ...
Roca-Umbert Würth, Ana (Date of defense: 2021-12-22)
Zinc is an essential micronutrient involved in many different biological processes. Zinc homeostasis is mainly regulated by 24 zinc transporters coded by the Zinc Transporter Genes (ZTGs). Notably, zinc ...
Pardo Lorente, Natalia (Date of defense: 2023-10-06)
Subcellular compartmentalisation of metabolic enzymes may elicit specific cellular functions by establishing a unique metabolic environment. Indeed, the nuclear translocation of certain metabolic enzymes ...
Marco Giménez, Andrés (Date of defense: 2022-03-14)
Our current knowledge about the function of human genes is mostly based on data from genetic studies using animal models. However, divergence among species may hamper the understanding of genetic ...