Serres Armero, Aitor (Date of defense: 2020-02-03)
L’estudi de la variació estructural complementa l’estudi de la variació de seqüència per revelar les complexitats de la variació fenotípica. Els gossos són l’espècie domesticada amb més variació fenotípica ...
Cubas Landaluce, Laura de (Date of defense: 2024-01-19)
Los efectos del H2O2 en la fisiología celular, como oxidante y como señalizador es un campo que aún esta en expansión. Para intentar desvelar como ocurren estos fenómenos, hemos utilizado sondas ...
Sanvicente García, Marta (Date of defense: 2023-05-18)
Precision and accuracy are paramount for the use of genome editing in clinic, environmental, and industrial applications. These fields require reliable and traceable results to ensure the safety and ...
Bauer, Moritz (Date of defense: 2020-02-14)
The reactivation of the inactive X chromosome has the potential to provide a unique system to study the developmentally induced formation of euchromatin. However, insights into this process were hampered ...
Kranas, Hanna (Date of defense: 2023-11-03)
Living cells are exposed to naturally occurring DNA-damaging agents that promote the loss of genome integrity, threatening the proper functioning of the cell. To counteract the toxic accumulation of DNA ...
Solís Moruno, Manuel (Date of defense: 2021-09-14)
Autoinflammatory diseases are caused by an antigen independent hyperactivation of inflammatory pathways. The first genetic defect linked to an autoinflammatory disease was described almost 25 years ago ...
Caro Consuegra, Rocío (Date of defense: 2023-02-15)
As a result of local selective pressures, genetic adaptation leaves distinct recognisable marks in the genomes of human populations. Several cases of positive natural selection have been described in ...
Oswal, Natasha Nikhil (Date of defense: 2023-06-08)
El envejecimiento implica un aumento de la fragilidad en función del tiempo que resulta en la aceleración de la mortalidad. Para comprender el papel temporal de varias proteínas en el envejecimiento, ...
Miravet Verde, Samuel (Date of defense: 2021-05-14)
Small proteins (SEPs; <100aa) are involved in essential processes such as cell homeostasis, signalling, or metabolism. However, they have been overlooked because of computational and experimental ...
Galan Martínez, Silvia (Date of defense: 2020-11-17)
El desenvolupament de tècniques experimentals basades en la captura de la conformació genòmica (3C), han aportat informació rellevant sobre l’estructura del genoma. En particular el Hi-C, un derivat del ...