Villegas Mirón, Pablo (Date of defense: 2021-07-19)
The evolutionary history of the human genome has been shaped by the selection of multiple elements in response to different environmental pressures. The analysis of regulatory adaptations and the ...
Vicencio, Jeremy (Date of defense: 2021-09-03)
In this thesis, I present an alternative, cloning-free method for the generation of endogenous fluorescent reporters in the nematode Caenorhabditis elegans. I demonstrate that Nested CRISPR is an efficient ...
Hinojosa Galisteo, Joan Carles (Date of defense: 2021-06-23)
Butterflies are among the best studied animals, but despite the research efforts carried out during centuries, our knowledge on their diversity and on the mechanisms generating it is still incomplete. In ...
Dios Martínez, Toni de (Date of defense: 2021-03-23)
Infectious diseases have affected humanity since its apparition in Africa 300,000 years ago. Demographic changes associated to the Neolithic transition, and ensuing population movements, have facilitated ...
Maceda Porto, Iago (Date of defense: 2021-04-28)
In this work we present a new whole genome sequencing dataset with samples gathered from the Spanish Eastern Pyrenees (SEP) with more than 40x coverage. We apply both classical and new methods to ...
Antonelli, Maria Carla (Date of defense: 2021-03-24)
During the last decades the non-coding portion of the genome became subject of intense research due to its contribution to the complexity of biological and pathological processes. CircRNAs are a class ...
López Blanch, Laura (Date of defense: 2021-04-30)
Neural microexons are the most conserved type of alternative splicing, suggesting a strong functional relevance. Consistently, mutation of their master regulators leads to dramatic neurodevelopmental ...
Meseguer Donlo, Alberto (Date of defense: 2021-07-02)
Las células de nuestro cuerpo son capaces de tener comportamientos y morfologías completamente diferentes, pese a contener el mismo material genético. Entre los mecanismos que permiten esta diversidad ...
Karamtzioti, Paraskevi (Date of defense: 2021-02-01)
This thesis aimed to characterize the tubulin PTM profile of human oocytes and spermatozoa. Tubulin rich structures play critical roles in the cellular behavior of human gametes. Mutations in tubulin ...
Borsari, Beatrice (Date of defense: 2021-03-26)
We have monitored the transcriptome and the epigenome of human pre-B cells transdifferentiating into macrophages. Analysis of these data provides a general framework to understand the relationship between ...