Domingo Espinós, Júlia (Date of defense: 2020-02-21)
The first aim of this thesis was to tackle a core question in biology—to understand how large numbers of mutations combine together to influence phenotypes. In order to do so, we built a combinatorial ...
Invergo, Brandon M. (Date of defense: 2013-11-22)
Phototransduction is the biochemical process by which a light stimulus is converted to a neuronal signal. The process functions through complex interactions between many proteins, which work in concert ...
Telford, Marco (Date of defense: 2017-12-19)
This thesis focuses on Human herpesvirus 4 and 6, two ubiquitous viruses with a long list of putative disease associations, ranging from malignancies such as lymphomas and carcinomas to multiple sclerosis. ...
Eliscovich, Carolina (Date of defense: 2008-06-11)
La progresión meiótica y el desarrollo embrionario temprano están programados, en parte, por la activación tradcuccional de mRNAs maternos como lo son los que codifican para las proteinas de ciclina B1 ...
Aigner, Johanna (Date of defense: 2013-11-25)
La família B7 de proteïnes és àmpliament reconeguda per jugar un paper important en els processos inflamatoris mitjançant l'alteració de la capacitat de resposta de les cèl•lules T. La unió d’aquestes ...
Herranz Martín, Nicolás (Date of defense: 2011-09-23)
The epithelial to mesenchymal transition (EMT) is a highly conserved cellular program that allows well-‐differentiated epithelial cells to convert to motile mesenchymal cells. ...
Hernández Rodríguez, Jéssica (Date of defense: 2018-06-08)
The innovation of genomics has progressed at pace with the development of high-throughput DNA sequencing technologies. Prior to the outbreak of next-generation sequencing, retrieving genetic information ...
Jiménez Asins, Alba (Date of defense: 2016-05-11)
Per tal d'estudiar la relació complexa entre l'estructura d'un circuit genètic i la seva funció, ens centrem en estudiar dues proprietas: la seva capacitat evolutiva i la seva multi-functionalitat. ...
Gallego Jiménez, Alicia (Date of defense: 2016-11-14)
microRNAs are small non-coding RNAs with crucial roles in gene regulation and whose contribution to animal evolution has been largely demonstrated. In this thesis we explored some functional consequences ...
Morey Ramonell, Lluís (Date of defense: 2008-02-01)
En mamíferos, así como en plantas, mutaciones en AND helicasas/ATPasas del la família SNF2, no solo afectan a la estructura de la cromatina, sino que también afectan al patrón global de la metilación ...