Moreno Ruiz, Nerea (Date of defense: 2024-06-25)
Rare disorders have been presumed to be caused by monogenic variation for decades, hindering the diagnosis in some cases. With many rare disease patients still missing a molecular diagnosis after genetic ...
Costanzo, Maria (Date of defense: 2024-06-26)
Stem cell-based in vitro systems have recently been used to complement the study of developmental processes in the embryo. Somitogenesis, which segments a vertebrate body axis to establish its characteristic ...
Valenzuela Seba, Alejandro (Date of defense: 2024-07-02)
In the current genomics era, it is essential to understand how the existing genomics diversity across evolution is linked to the enormous diversity we observe at the phenotypic level. Until now, Genome-wide ...
Montañés Domínguez, José Carlos (Date of defense: 2024-07-11)
This thesis analyzes the generation of new genes created de novo and evaluates their evolution mainly in yeast but also in flies. First of all, we used next generation sequencing technology to analyze ...
Borao Arriazu, Sonia (Date of defense: 2022-07-22)
Schizosaccharomyces pombe initiates sexual development under nitrogen starvation, changing the transcription patterns of many genes to allow sexual differentiation. MBF transcription factor recognize ...