Mostrando ítems 51-60 de 176
García-Prat, Laura (Fecha de defensa: 2015-10-14)
During aging, muscle stem cell regenerative function declines, being maximal at advanced geriatric age, due to a quiescence-to-senescence transition. How quiescence is maintained over long periods of ...
Inglés Ferrándiz, Marta (Fecha de defensa: 2018-12-14)
In this thesis, we have been studying the role of UNR, and RNA-binding protein that regulates translation and/or stability of its targets. The functional relevance of UNR was studied in two different ...
Batlle Gómez, Raquel (Fecha de defensa: 2011-12-19)
The Snail1 transcriptional repressor is a key factor responsible in triggering epithelial to mesenchymal transition. Although Snail1 is widely expressed in early development, it is limited in adult ...
Nadimpalli, Hima Priyanka (Fecha de defensa: 2017-12-11)
Cytoplasmic polyadenylation is a widespread mechanism to control mRNA translation. In vertebrates, this mechanism requires two sequence elements in the 3’ UTR of substrate mRNAs, the U-rich Cytoplasmic ...
Di Mauro, Gianmarco (Fecha de defensa: 2019-02-28)
Dsk2/UBQLN is a conserved extraproteasomal ubiquitin receptor that has been widely described as a protein involved in the ubiquitin proteasome pathway. In Drosophila, this protein has been recently ...
Tilgner, Hagen (Fecha de defensa: 2011-06-02)
L’Splicing de les molècules d’ARN és el procés pel qual les seqüències interposades (“introns”) s’eliminen, i les seqüències restants es concatenen per a formar l’ARN madur. La investigació recent ...
Bascones Gleave, Sabrina (Fecha de defensa: 2016-12-20)
The spleen contains a unique subset of innate-like marginal zone (MZ) B cells that rapidly mount protective antibody responses to invasive encapsulated bacteria. Here we show that human splenic MZ B ...
Costa García, Marcel (Fecha de defensa: 2018-06-11)
Human cytomegalovirus (HCMV) infection induces persistent changes in the host immune system, namely a sustained expansion of effector memory and cytotoxic specific T lymphocytes, the production of ...
Cebrià i Costa, Joan Pau (Fecha de defensa: 2017-06-29)
L’oxidació de la histona 3 en la lisina 4 (H3K4ox) per acció de la lysil oxidase-like 2 (LOXL2) genera una nova modificació de la H3 amb una funció desconeguda. En aquesta tesi, hem determinat tant en ...
Pascual-Reguant, Laura (Fecha de defensa: 2018-11-23)
Les làmines nuclears (A/C i B) són els majors constituents de la làmina nuclear (NL). Els estructuralment conservats dominis associats a les làmines (LADs) estan formats per regions genòmiques que ...