Rosas Salvans, Miquel (Date of defense: 2017-12-19)
Three microtubule (MT) assembly pathways participate in the assembly of the bipolar spindle: the centrosomal pathway, the augmin dependent amplification pathway and the RanGTP/chromosome dependent ...
Mantica, Federica (Date of defense: 2023-05-11)
Regulated Gene Expression (rGE) and Alternative Splicing (rAS) are two of the main mechanisms contributing to tissue-phenotypic diversity within and between species. In this thesis, we aim at characterizing ...
Ferrer i Admetlla, Anna (Date of defense: 2009-01-07)
La tesi que teniu a les mans recull quatre treballs amb un objectiu comú; determinar si els patògens (virus, bacteris, paràsits.) han exercit pressions selectives sobre els genomes dels seus hostes (com ...
Frías Hernández, Àlex (Date of defense: 2015-12-10)
Notch activation in aortic endothelial cells (ECs) takes place at embryonic stages during cardiac valve formation and induces an endothelial-to-mesenchymal transition (EndMT). Using aortic ECs, we show ...
Vázquez Ferrer, Eric (Date of defense: 2017-11-10)
It has been well-established that progressive accumulation of genetic mutations in proto-oncogenes and tumor suppressors induces cancer. However, the early molecular mechanisms leading to tumor initiation ...
Cornes Maragliano, Eric (Date of defense: 2015-07-24)
Lsm proteins regulate RNA metabolism and are conserved in the three domains of life, typically functioning as RNA-binding complexes involved in a wide range of post-transcriptional mechanisms. Generally, ...
Drews-Elger, Katherine (Date of defense: 2008-11-07)
The transcription factor NFAT5/TonEBP belongs to the Rel family, which also comprises NF ÛB and NFATc proteins. NFAT5 only shares structural and functional homology with other Rel family members at the ...
Amaral, Nuno (Date of defense: 2016-01-22)
La coordinació de la citocinesis amb la segregació cromosòmica és essencial per mantenir l’estabilitat cromosòmica durant la proliferació cel•lular. Tant en llevat com en cèl•lules animals, els ponts ...
Pittis, Alexandros (Date of defense: 2016-10-14)
The origin of eukaryotic compartmentalization stands as a major conundrum in biology. Current evidence indicates that the last eukaryotic common ancestor (LECA) already possessed many eukaryotic hallmarks, ...
Titos Vivancos, Iris (Date of defense: 2013-10-25)
At the metaphase-to-anaphase transition, spindle microtubules pull replicated chromosomes to the daughter cells, but full separation of long chromosome arms is achieved in late anaphase. We have created ...