Traveset Martínez, Laia (Date of defense: 2020-10-30)
Maintenance of steady-state and stress-adapted hematopoiesis depends on the fitness of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow. Hematopoietic stem cells (HSCs) can adapt to ...
Isús Díaz, Laura (Date of defense: 2017-02-13)
Since the advent of the genomic era, vast amounts of data from heterogeneous biomedical sources have been generated, revealing an overwhelming complexity and creating a need for new computational tools. ...
Millanes Romero, Alba (Date of defense: 2014-01-21)
Although heterochromatin is enriched with repressive traits, it is actively transcribed, giving rise to large amounts of non-coding RNAs. These transcripts are responsible for the formation and ...
Gentile, Maurizio (Date of defense: 2014-09-19)
The marginal zone (MZ) of the spleen contains an innate-like subset of B cells that mount rapid protective antibody responses to polysaccharides and lipids from bloodborne viruses and bacteria. These ...
Mestre Farràs, Neus (Date of defense: 2021-09-16)
La tesi doctoral aquí presentada busca entendre quin és el paper de les proteïnes d’unió a l’ARN en la progressió tumoral, ja que s’ha demostrat que aquestes proteïnes poden regular aspectes que permeten ...
Severino, Jacqueline (Date of defense: 2021-03-30)
X chromosome reactivation in female mouse germ cells is essential for the transmission of one active X chromosome to the progeny. However, despite its key role in development, the mechanistic details and ...
Rosas Salvans, Miquel (Date of defense: 2017-12-19)
Three microtubule (MT) assembly pathways participate in the assembly of the bipolar spindle: the centrosomal pathway, the augmin dependent amplification pathway and the RanGTP/chromosome dependent ...
Ferrer i Admetlla, Anna (Date of defense: 2009-01-07)
La tesi que teniu a les mans recull quatre treballs amb un objectiu comú; determinar si els patògens (virus, bacteris, paràsits.) han exercit pressions selectives sobre els genomes dels seus hostes (com ...
Frías Hernández, Àlex (Date of defense: 2015-12-10)
Notch activation in aortic endothelial cells (ECs) takes place at embryonic stages during cardiac valve formation and induces an endothelial-to-mesenchymal transition (EndMT). Using aortic ECs, we show ...
Vázquez Ferrer, Eric (Date of defense: 2017-11-10)
It has been well-established that progressive accumulation of genetic mutations in proto-oncogenes and tumor suppressors induces cancer. However, the early molecular mechanisms leading to tumor initiation ...