Cabrerizo Granados, David (Date of defense: 2020-11-30)
Snail1 is a transcriptional factor with a great relevance in tumor development as it is required for epithelial to mesenchymal transition and activation of cancer-associated fibroblasts (CAF). In this ...
Storer, Mekayla (Date of defense: 2014-12-18)
Cellular senescence is an irreversible form of proliferative arrest, historically linked to tumour suppression and aging. Recent discoveries, however, have extended its known role to include complex ...
Magri, Giuliana (Date of defense: 2011-03-31)
S'ha establert un sistema experimental autòleg per a poder estudiar la resposta de les cèl.lules Natural Killer (NK) contra les cèl.lules dendrítiques derivades de monòcits (moDC), infectades pel ...
Montagni, Elisa (Date of defense: 2015-11-09)
The first chapter identifies the transcription factor GATA6 as negative regulator of a transcriptional circuit dedicated to prevent the expansion of Adenoma Stem Cells (AdSCs) during the onset of ...
Sebastián Perez, Rubén (Date of defense: 2021-09-10)
Chromocenters are established after the 2-cell (2C) stage during mouse embryonic development, but the factors that mediate chromocenter formation remain largely unknown. To identify regulators of 2C ...
Andrés Aguayo, Luisa de (Date of defense: 2017-05-05)
The life-long production of blood cells is enabled by hematopoietic stem and progenitor cells (HSPC) residing in the bone marrow. An understanding of the genes that control how HSPCs work to sustain the ...
Lambies Barjau, Guillem (Date of defense: 2019-01-10)
Cancer cells undergo epithelial-to-mesenchymal transition (EMT) to dissociate from the primary tumor and to survive to chemotherapy. EMT is controlled by Snail1, a transcriptional factor also required ...
Islam, Abul (Date of defense: 2012-06-25)
Recent advances in high throughput technology have opened the door to systematic studies of epigenetic mechanisms. One of the key components in the regulation of the cell cycle and differentiation is ...
Tapial Rodríguez, Javier (Date of defense: 2018-12-14)
Alternative splicing (AS) is a post-transcriptional mechanism for gene expression regulation affecting almost every multiexonic gene in mammals. However, the impact of AS at the proteomic level remains ...
Dan, Yuzhen (Date of defense: 2022-02-24)
p38α (encoded by MAPK14) is a major regulator of cellular responses to almost all types of environmental and intracellular stresses. Upon activation, p38α phosphorylates various substrates both in the ...