Barba Moreno, Laura (Date of defense: 2018-06-22)
DYRK1A (dual-specificity tyrosine-regulated kinase 1A) belongs to a conserved family of protein kinases present in all eukaryotes. DYRK1A is known to participate in cell proliferation and differentiation ...
Roewenstrunk, Julia Maria (Date of defense: 2016-12-19)
Gene dosage alterations of the kinase DYRK1A are linked to disease in humans. To better understand DYRK1A activities an interactome analysis was performed. RNF169, an E3-ubiquitin ligase key component ...
Hernández Ribera, Jordi (Date of defense: 2016-11-23)
Alternative pre-mRNA splicing of the Notch regulator NUMB exon 9 switches between isoforms that promote (exon inclusion) or prevent (exon skipping) cell proliferation. We have studied NUMB alternative ...
Doerr, Stefan (Date of defense: 2016-09-16)
Molecular dynamics has established itself over the last years as a strong tool for structure-based molecular investigation in biology. Stefan Doerr's thesis concerns the application of machine learning ...
Vigevani, Luisa (Date of defense: 2016-11-21)
RNA splicing is the process of removal of introns from pre-mRNAs. It is carried out by the spliceosome, composed of five small nuclear ribonucleoproteins (snRNPs). Several small molecules with antitumor ...
Regot Rodríguez de Mier, Sergi (Date of defense: 2011-07-15)
A fundamental property of living cells is the ability to sense and respond appropriately to changing environmental conditions. In budding yeast (Sacharomyces cerevisiae), changes in extracellular osmotic ...
Kemena, Carsten (Date of defense: 2012-12-12)
Sequence alignment is one of the basic methods to compare biological sequences and the cornerstone of a wide range of different analyses. Due to this privileged position at the beginning of many studies ...
Viéitez Manrique, Cristina (Date of defense: 2014-12-18)
In response to fluctuations in the environment, all living organisms have the ability to sense, respond and adapt to the new conditions. In budding yeast (Saccharomyces cerevisiae) there is a massive ...
Poglayen, Daniel (Date of defense: 2016-01-28)
Cellular behaviour is regulated by a very precise system in which the complex interplay between various types of biomolecules plays a crucial role for the proper functioning of the system itself. Proteins ...
Ashok, Anupama (Date of defense: 2019-01-21)
COPII vesicles of 60-90nm diameter are known to export secretory cargoes from endoplasmic reticulum (ER). However, they cannot be employed to export bulky cargoes like the collagens that can reach up ...