Campagna, Anne (Date of defense: 2012-02-17)
Interactions between proteins give rise to many functions in cells. In the lastdecade, highthroughput experiments have identified thousands of protein interactions, which are often represented together ...
Kiefer, Kerstin (Date of defense: 2016-05-12)
Genome-wide association studies linked increased ORMDL3 expression levels to several inflammatory diseases via single nucleotide polymorphisms. However, the pathophysiological mechanisms underlying this ...
Talló Parra, Marc (Date of defense: 2019-12-17)
La rellevància clínica dels virus transmesos per mosquits, com el virus del dengue (DENV), el virus del zika (ZIKV), el virus del chikungunya (CHIKV) i el virus del Nil Occidental (WNV), ha augmentat ...
García Beyaert, Marina (Date of defense: 2016-01-27)
Regulation of msl2 translation is a key step in the modulation of X-chromosome dosage compensation. MSL2 is the limiting subunit of the dosage compensation complex, an assembly that promotes hyper-transcription ...
Kessler, Roman (Date of defense: 2014-06-03)
Unlike characteristic HP1 proteins, the HP1c isoform of Drosophila melanogaster is a euchromatic protein. HP1c forms a complex with the zinc finger proteins ROW and WOC, which are crucial for HP1c ...
Mejetta, Stefania (Date of defense: 2013-09-12)
Jarid2 is required for the genomic recruitment of the polycomb repressive complex-2 (PRC2) in embryonic stem cells. However, its specific role during late development and adult tissues remains ...
Rai, Madhulika (Date of defense: 2018-01-29)
Genetically tractable model organisms may help to identify new approaches to stop malignant growth. During the first part of my doctoral thesis, I have participated in a high content screen carried ...
Cort, Rianne Angelica (Date of defense: 2019-12-13)
The kinase DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a dosage-sensitive gene, since both haploinsufficiency and overexpression when in trisomy lead to pathological phenotypes in humans. ...
Gibert Fernandez, Joan (Date of defense: 2017-11-08)
Cytoplasmic polyadenylation binding proteins (CPEB) are a family of RNA binding proteins which control the translation of its target mRNAs by modulating the length poly(A) mRNA tail. Cytoplasmic ...
Campos Mata, Leire de (Date of defense: 2019-12-18)
The highly conserved exonuclease Xrn1 plays a dual role in gene expression by degrading cellular mRNAs and promoting their transcription initiation and elongation. In this thesis we uncover an unanticipated ...