Joy, Jery (Date of defense: 2020-02-03)
Chromosomal Instability (CIN) and associated aneuploidy are salient features of the majority of human solid tumors. In the Drosophila epithelial model of CIN, the generation of highly aneuploid karyotypes ...
Fraile Beneitez, Rodrigo (Date of defense: 2021-07-23)
Eukaryotic DNA is condensed inside the nucleus, compacted into chromatin. The structure of chromatin is dynamic, and its accessibility to cellular machinery can be altered depending on the level of ...
Varela Rial, Alejandro (Date of defense: 2022-02-21)
The affinity of a drug to its target protein is one of the key properties of a drug. Although there are experimental methods to measure the binding affinity, they are expensive and relatively slow. ...
Blevins, William Robert (Date of defense: 2020-01-17)
All living organisms respond to environmental stimuli by modulating the activity of different genes. This response can occur across many locations throughout the cell such as at the level of transcription, ...
Espejo Díaz, María Isabel (Date of defense: 2021-09-20)
Polycomb group (PcG) proteins are transcriptional repressors that control development and cell fate. Polycomb Repressive Complex 2 (PRC2) misfunction has been recurrently associated with embryonic ...
Cid Samper, Fernando (Date of defense: 2020-01-27)
Ribonucleoprotein granules (RNP granules) are liquid-liquid phase separated complexes composed mainly by proteins and RNA. They are responsible of many processes involved in RNA regulation. Alterations ...
Marte, Luis (Date of defense: 2020-01-31)
Proteostasis is the proper homeostasis of the concentration and the molecular structure of the proteins, which preserves the integrity of the proteome. Proteo-stasis is constantly challenged by intrinsic ...
Horváth, Vivien (Date of defense: 2020-09-28)
Environmental stress is a major aspect of life and a limiting factor for the survival and distribution of species. Understanding the organismal stress response and the developed coping mechanisms is ...
Armaos, Alexandros (Date of defense: 2020-01-23)
Despite what was previously considered, the role of RNA is not only to carry the genetic information from DNA to proteins. Indeed, RNA has proven to be implicated in more complex cellular processes. ...
Herrera Nieto, Pablo (Date of defense: 2020-07-17)
Over the last decades molecular dynamics simulations have been successfully applied to relevant biological problems such as protein-ligand, protein-protein binding as well as protein folding. A perfect ...