Cornet Bartolomé, Carles (Date of defense: 2020-01-17)
High drug attrition rate during clinical and post market phases is one of the major factors contributing to the pharmaceutical industry productivity crisis. This problem is especially worrisome in the ...
Martínez Rosell, Gerard (Date of defense: 2017-12-20)
In this thesis we apply molecular dynamics (MD) simulations and other in silico techniques in drug discovery. Specifically, (a) we developed an algorithm to detect cryptic pockets based on MD simulations ...
Olivés Farrés, Joaquim (Date of defense: 2017-01-30)
L'habilitat de petites molècules per interaccionar amb múltiples proteines no és exclusiva dels fàrmacs, sino de la majoria de compostos, incloent els metabòlits endogens dels organismes, desde les ...
Pérez-Peinado, Clara (Date of defense: 2020-01-20)
This work describes the discovery and optimization of efficient, selective, cost-effective and proteolytic-resistant antimicrobial and antitumoral peptides. To this end, we first identified novel ...
Fabregat Rossell, Andreu (Date of defense: 2014-07-16)
The detection of endogenous anabolic androgenic steroids (EAAS) is one of the most difficult analytical challenges in the doping control field. The main problem for their detection is to distinguish ...
Coll Camenforte, Sergi (Date of defense: 2019-12-10)
Due to health risks associated to the use of glucocorticoids (GC) and their potential ergogenic effects, systemic GCs are prohibited in sports competitions. However, local GC administrations are allowed ...
Mallorquí Bagué, Joaquim (Date of defense: 2011-04-28)
Erythropoietin (EPO) is a glycoprotein hormone, the molecule comprises a single polypeptide chain of 165 aminoacids with two disulfide bonds, 1 O-linked (Ser-126), and 3 N-linked (Asn-24, 38, 83) glycans ...
Cantacorps Centellas, Lídia (Date of defense: 2019-11-15)
Maternal alcohol binge drinking during pregnancy can be deleterious for the developing foetus, leading to a wide range of long-lasting morphological and neurobehavioural disabilities known as foetal ...
Martínez-Jiménez, Francisco (Date of defense: 2016-12-16)
Most of the cellular functions are driven by small-molecules that selectively bind to their protein targets. Is such their importance, that the pharmacological intervention of proteins by small molecule ...
Orejarena, Maria Juliana (Date of defense: 2010-09-06)
(+) 3,4-metilendioximetanfetamina (MDMA), popularmente conocida como "éxtasis", es una droga susceptible de producir adicción en algunos individuos. Actualmente es consumida principalmente por adolescentes ...