Millán Ariño, Lluís (Date of defense: 2013-11-25)
Seven linker histone H1 variants exist in human somatic cells with distinct prevalence among cell types and during differentiation. Despite being key chromatin structural components, it remains elusive ...
Espeso Gil, Sergio (Date of defense: 2016-12-05)
El reguloma està constituït per un sistema complex de factors que controlen el fenotip molecular de la cèl·lula, que al seu torn està influenciada pel medi ambient. Qualsevol pertorbació pot desencadenar ...
Balducci, Elisa (Date of defense: 2012-02-24)
Cerebral cortex is essential to exert the highest functions in mammals. Understanding the developmental processes that underlie the generation and functionality of cortical cell populations represents ...
Kłosin, Adam (Date of defense: 2015-11-09)
Desde Darwin y Lamarck, a los biólogos les ha intrigado la posibilidad de que rasgos adquiridos debido al ambiente pudieran ser heredados. Se han descrito muchos ejemplos de este tipo debidos a ...
Sayols Baixeras, Sergi (Date of defense: 2019-02-18)
La malaltia cardiovascular, que és primera causa de mortalitat al món, com a fenotip complex depèn tant dels factors ambientals com dels genètics. Les variants genètiques comunes expliquen un 15-20% ...
Pohl, Andy (Date of defense: 2014-10-03)
Genome-wide analysis of the nucleosome positioning and histone H1 isoform content of the T47D breast cancer cell line has found a number of observations, namely that with a gentle digestion of microccocal ...
Mateu Jiménez, Mercè (Date of defense: 2017-12-18)
Chronic respiratory diseases, especially chronic obstructive pulmonary disease (COPD), and several molecular mechanisms may predispose to lung cancer (LC) development. Hypothesis: We hypothesized that ...
Serra Juhé, Clara (Date of defense: 2012-10-20)
Mechanisms underlying congenital malformations are largely unknown despite its high incidence, affecting 2-3% of liveborn infants. A broader knowledge about the causes of birth defects would provide ...
González Ramírez, Mar (Date of defense: 2021-03-19)
Appropriate regulation of gene expression is necessary for correct development and homeostasis of organisms. Epigenetic mechanisms represent an additional layer of information, besides the genetic ...
Tarruell Pellegrin, Antonio (Date of defense: 2019-06-26)
In female mammals, one of the X chromosomes is epigenetically inactivated through X chromosome Inactivation (XCI) during the epiblast differentiation. However, XCI is later specifically reversed in ...