Torres Méndez, Antonio (Date of defense: 2020-02-28)
Post-transcriptional networks control multiple aspects of neuronal biology and their deregulation has been associated with human neurological disorders. This thesis focuses on regulation at the level ...
Bonforti, Adriano (Date of defense: 2022-07-27)
L'aparició de la pluricel·lularitat (MC) va definir un esdeveniment evolutiu important en la història de la vida al nostre planeta. Ha tingut lloc diverses vegades dins de grups independents i diferents ...
López Valenzuela, María (Date of defense: 2015-01-15)
MicroRNAs (miRNAs) are major contributors to phenotypic diversity and have a demonstrated role in evolution. We performed an analysis on how miRNA nucleotide substitutions may have contributed to human ...
Verd Fernández, Berta (Date of defense: 2016-01-21)
During insect development segments either form sequentially (short-germband) or simultaneously (long-germband) . The gap genes comprise the first zygotic regulatory layer of the segmentation gene ...
Mondal, Mayukh (Date of defense: 2016-11-21)
Human genome project published their first human whole genome sequence on 2001 at the cost of billions of dollars. Since, the cost of sequencing is decreasing faster than Moore’s law. Now, we not only ...
Heredia Genestar, José María (Date of defense: 2020-01-28)
La mutació és un procés essencial per l’evolució, tot i que també té un rol important tant en el càncer com en altres malalties. Les mutacions no s’acumulen uniformement al llarg del genoma i la seva ...
Burga Ramos, Alejandro Raúl (Date of defense: 2012-07-20)
Genetically identical cells and organisms growing in homogenous environmental conditions can show significant phenotypic variation. Furthermore, mutations often have consequences that vary among individuals ...
Bello, Carla (Date of defense: 2017-12-15)
La identificación de elementos funcionales en el genoma no-codificante continúa siendo una tarea desafiante. La genómica comparativa puede ayudarnos a entender como estos elementos han evolucionado y ...
Renom, Pere (Date of defense: 2023-02-22)
According to estimates, over the 3.5 billion years that have elapsed since the appearance of life, the Earth has been inhabited by some 4 billion different species, of which 99.99% have already become ...
Elek, Anamaria (Date of defense: 2024-04-19)
Single-cell genomics methods have revolutionized the study of gene expression and regulation at the cell type level. Generating single-cell atlases for species at key phylogenetic positions of the animal ...