Tolosa Ramon, Queralt (Date of defense: 2023-07-26)
The outer epithelial layer is the first cell type that emerges during development, providing essential mechanical protection and is indispensable for morphogenesis. Here, we study how the interplay ...
Martínez Fernández, Carmen (Date of defense: 2021-03-12)
Model organisms and gene-editing strategies are fundamental to address a variety of scientific questions from basic science to biomedical research. Here, we reinforced the use of two powerful tools, ...
Avila-Palencia, Ione (Date of defense: 2018-11-21)
Urban environments are very complex systems with a myriad of factors intricately related. Built environment, transport, physical activity and sedentary behaviours, air pollution, and social contacts and ...
Jiménez Luna, José (Date of defense: 2019-10-24)
Deep learning approaches have become increasingly popular in the last years thanks to their state-of the-art performance in fields such as computer vision and natural language understanding. The first ...
Padró i Jové, Mercè (Date of defense: 2011-03-28)
Alterations in the expression of carbohydrates and the enzymes involved in their synthesis (glycosidases and glycosyltransferases) can be considered as universal feature of malignant transformation. ...
Amodio, Francesco (Date of defense: 2015-06-11)
This thesis provides an empirical investigation of externalities and social interaction mechanisms in various settings. In the first chapter, I show how input heterogeneity triggers productivity spillovers ...
Gabrielli, Natalia (Date of defense: 2012-12-04)
Hydrogen peroxide (H2O2), a reactive oxygen species (ROS), is involved in both oxidative stress and signaling cascades in a dosage dependent manner. Its toxicity is partially explained through reactivity ...
Espejo Díaz, María Isabel (Date of defense: 2021-09-20)
Polycomb group (PcG) proteins are transcriptional repressors that control development and cell fate. Polycomb Repressive Complex 2 (PRC2) misfunction has been recurrently associated with embryonic ...
Engel-Pizcueta, Carolyn (Date of defense: 2023-04-28)
The generation of cell diversity in the embryonic brain relies on the balance between cell proliferation and differentiation. The hindbrain boundary cells specify at the interface between adjacent ...
Viñas Castells, Rosa (Date of defense: 2013-05-24)
Epithelial to mesenchymal transition (EMT) is a process by which epithelial cells acquire a mesenchymal phenotype. It is characterized by the down-regulation of the adherens junction protein E-cadherin, ...