Cuenca Cortés, Alejandro (Date of defense: 2023-05-17)
Nuclear pore complexes (NPCs) are necessary for stem cell maintenance, cell fate determination, and the aging process. The specific contribution of NPCs to the physiology of muscle stem cells (satellite ...
Altadill Balsells, Mireia (Date of defense: 2023-06-30)
Human cytomegalovirus (HCMV) causes a prevalent lifelong infection in all human populations. Although the course is generally mild and the virus remains latent, HCMV can cause severe disorders in ...
Martínez Ara, Guillermo (Date of defense: 2022-09-19)
During embryonic development, cellular forces synchronize in space and time to generate functional tissue shapes. Apical constriction is a force-generating process necessary to provoke the folding of ...
Cuenca-Ardura, Mirabai (Date of defense: 2024-01-19)
HNF1A encodes a key transcription factor in insulin-secreting beta cells from pancreatic islets. Heterozygous mutations in HNF1A cause monogenic diabetes, and hypomorphic variants in HNF1A increase ...
Galán i Palma, Luis (Date of defense: 2023-03-22)
Pluripotent stem cells (PSCs) have the ability to self-renew and give rise to almost every somatic cell type. Because of their enormous potential as a tool for regenerative medicine, understanding ...
Tolosa Ramon, Queralt (Date of defense: 2023-07-26)
The outer epithelial layer is the first cell type that emerges during development, providing essential mechanical protection and is indispensable for morphogenesis. Here, we study how the interplay ...
Engel-Pizcueta, Carolyn (Date of defense: 2023-04-28)
The generation of cell diversity in the embryonic brain relies on the balance between cell proliferation and differentiation. The hindbrain boundary cells specify at the interface between adjacent ...
Mantica, Federica (Date of defense: 2023-05-11)
Regulated Gene Expression (rGE) and Alternative Splicing (rAS) are two of the main mechanisms contributing to tissue-phenotypic diversity within and between species. In this thesis, we aim at characterizing ...
Tu, Xiaochuan (Date of defense: 2023-07-27)
Embryonic stem cells (ESCs) are derived from the inner cell mass of the pre-implantation embryo and can recapitulate early developmental stages of the embryo. ESCs have the ability to continuously ...
Higuera González, Laura (Date of defense: 2021-10-01)
Macrophages play crucial roles in the defense of the organism against a wide range of pathogens. Macrophages can rapidly adapt to perturbations in the microenvironment due to the existence of a network ...