Demajo Meseguer, Santiago (Date of defense: 2014-02-21)
Acute myeloid leukemia (AML) is frequently linked to epigenetic abnormalities and deregulation of gene transcription, which lead to aberrant cell proliferation and accumulation of undifferentiated ...
Rinaldi, Lorenzo (Date of defense: 2016-10-17)
DNA methylation is an essential epigenetic mechanism that regulates gene expression. While DNA methylation dynamics during embryonic formation is fairly well understood, its role in adult tissues is ...
Jain, Payal (Date of defense: 2015-06-11)
Polycomblike proteins (PCLs) have been shown to regulate Polycomb Repressive Complex 2 (PRC2) by enhancing its catalytic activity and guiding PRC2 to its target genes in embryonic stem cells. However, ...
Chammas, Paul (Date of defense: 2019-11-29)
Polycomb repressive complex 2 (PRC2) is a key epigenetic regulator of gene expression. It acts through its histone-modifying activity, as it is responsible of di- and trimethylating the tail of histone ...
Uribesalgo Micàs, Iris (Date of defense: 2010-11-24)
The c-Myc transcription factor is a key player in cell homeostasis, being commonly deregulated in human carcinogenesis. In this PhD thesis we have addressed the question how regulatory mechanisms ...