Millán Ariño, Lluís (Date of defense: 2013-11-25)
Seven linker histone H1 variants exist in human somatic cells with distinct prevalence among cell types and during differentiation. Despite being key chromatin structural components, it remains elusive ...
Ramírez Cuéllar, Angélica Julieta (Date of defense: 2022-05-12)
In this Thesis we report the successful growth of hormone responsive T47D cells as 3D spheroids in Matrigel mimicking the ECM. A detailed characterization by using a genome-wide approach of the main ...
Pascual-Reguant, Laura (Date of defense: 2018-11-23)
Les làmines nuclears (A/C i B) són els majors constituents de la làmina nuclear (NL). Els estructuralment conservats dominis associats a les làmines (LADs) estan formats per regions genòmiques que ...
Sancho Medina, Mònica (Date of defense: 2008-05-30)
At least eleven histone H1 variants exist in mammalian somatic cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition of ...
Ricci, Maria Aurelia (Date of defense: 2015-06-05)
La arquitectura del genoma y la estructura de la cromatina, junto con los factores de transcripción son actores clave para la autorenovación, la pluripotencia y la diferenciación de las células madre ...
Martinez Sarmiento, Jose Angel (Date of defense: 2023-05-04)
Elucidating the mechanism of somatic cell reprogramming has been hampered by the limitations of iPSC systems to uncover the correctly reprogramming cells. Here, by using the highly efficient heterokaryon ...
Ruiz Roig, Clàudia (Date of defense: 2011-12-02)
A Saccharomyces cerevisiae, un increment de la temperatura comporta diversos efectes deleteris en l’organització interna de la cèl∙lula i indueix una inducció ràpida, massiva i transitòria d’expressió ...
Condemi, Livia (Date of defense: 2024-03-07)
Polycomb repressive complex (PRC) 2 is one of the key regulators of the transcriptional programs, it maintains stem cell properties and guides cell lineage specification. It is a multiprotein complex ...