Mostrando ítems 1-9 de 9
Arcas Mantas, Aida (Fecha de defensa: 2013-04-25)
The DNA Damage response is a crucial signaling network that preserves genome integrity. This network is an ensemble of distinct but often overlapping sub-networks, where participating components exert ...
Mugianesi, Francesca (Fecha de defensa: 2022-06-02)
Gene expression, epigenetic states and topological conformation are three fundamental aspects of genome organization that are tightly regulated in space and time. Epigenetic states, protein occupancy ...
Corrales Berjano, Marc (Fecha de defensa: 2018-01-19)
This thesis reports the study of chromatin composition and conformation on the expression of integrated reporters at thousands of genomic locations in the Drosophila genome. We have adapted and improved ...
Mocavini, Ivano (Fecha de defensa: 2022-03-31)
Polycomb repressive complex (PRC)1 and 2 are major players in gene regulation, devoted to maintenance of the epigenetic memory of gene silencing. Mouse embryonic stem cells (mESCs) have been extensively ...
Ortells Campos, Mª Carmen (Fecha de defensa: 2012-07-26)
Adaptive responses allow cells to maintain their growth as well as their proliferative potential under diverse stress conditions. It is known that, growth and proliferation can be suppressed by intense ...
Bauer, Moritz (Fecha de defensa: 2020-02-14)
The reactivation of the inactive X chromosome has the potential to provide a unique system to study the developmentally induced formation of euchromatin. However, insights into this process were hampered ...
Agirre Ortiz de Guzmán, Eneritz (Fecha de defensa: 2013-06-21)
Generalment s'ha pensat que la regulació de l'splicing alternatiu està controlada principalment per la interacció entre els factors reguladors de l'splicing i la taxa d'elongació de la ARN polimerasa ...
Kremsky, Isaac Jacob (Fecha de defensa: 2015-07-14)
Proteins that bind to DNA or RNA are both known to influence alternative splicing. However, there has not been so far a systematic experimental exploration of the relationship between these factors ...
Martín de Dios, Laura (Fecha de defensa: 2024-05-06)
La organización del genoma en células mamíferas sigue siendo en gran parte desconocida. Un nivel fundamental de organización se considera el bucle de cromatina, que consiste en una región de ADN atrapada ...