Universitat Pompeu Fabra: Recent submissions
Now showing items 1-20 of 3350
Newborn's Well-Being within War Context in Colombia
Prior to the 2016 Havana Peace Agreement, Colombia grappled with 70 years of violence stemming from an armed conflict involving military forces, guerrillas, and paramilitaries, profoundly impacting civilians, including ...
The Political Dynamics of Technological Change: Building States with Technology
In this thesis I analyze the political dynamics of technological change. Firstly, by studying the political causes of the advent of telecommunications, and secondly, by exploring the consequences of different technologies. ...
Global AI policy in the making: actors, framings, and approaches
The rapid advances in artificial intelligence (AI) technologies have sparked regulatory and political activities in jurisdictions around the world. This dissertation outlines and investigates the nascent domain of global ...
Building Trust Among Actors Within Regulatory Regimes: The Role of Specialized Agencies
Regulatory regimes have become increasingly complex due to a shift towards specialized agencies, particularly notable in multi-level contexts like the European Union where decision-making authority is dispersed across ...
Essays in Behavioral Science
In this thesis, I explore three topics in behavioral science. In the first chapter, we propose and test a new approach to making defaults more effective: asking people to justify their decision if they want to deviate ...
Inside the Black Box of Innovations: Understanding Impacts on Occupations and Task Content in Germany and Spain
This thesis investigates the determinants of innovation and its impact on occupational change and work tasks within the institutional contexts of Germany and Spain. The first chapter reveals that product and process ...
Inference of selection acting on coding sequences in the human lineage
Selection forces have shaped the current human DNA sequence through evolution. These forces have been consistently changing, in magnitude and direction, across the different evolutionary episodes of the extant human ...
A New in vitro model to study the regulatory functions of β cells in early stages of type1 diabetes
Type 1 Diabetes (T1D) is an autoimmune disease marked by the selective destruction of pancreatic β cells. Early insulitis involves interactions between immune cells and β cells, but the mechanisms leading to β cell death ...
Quantifying cellular behavior during early mammalian development
In this thesis we study cell behaviours such as cellular decision making and self-organization using the developing mouse embryo as the system of study. To be able to extract the most needed cellular dynamics from ...
Interrogating the importance of x-chromosome inactivation and reactivation for meiotic potential
X-chromosome dosage compensation in female mammals is achieved through X-chromosome inactivation (XCI), where one X chromosome is epigenetically silenced to ensure dosage parity with male cells. During germline development, ...
Deciphering lymphoma-specific DNA methylation alterations in healthy B cells: a single-cell multiomics study
Recent studies have shown that clones harboring cancer driver mutations colonize our tissues as we age. It remains to be determined whether the same is true for epigenetic alterations, specifically DNA methylation (DNAm) ...
Dissecting motor behaviour alterations in Parkinson's disease using genetically modified zebrafish models
Los trastornos neurodegenerativos como la enfermedad de Parkinson (EP) implican la degeneración progresiva del sistema nervioso, lo que provoca alteraciones tanto motoras como cognitivas. La EP afecta a millones de personas ...
Decoding the regulatory grammar of hematopoiesis using synthetic enhancers
During cellular differentiation, gene regulatory elements (GREs) play a crucial role in converting expression gradients of transcription factors (TF) into precise target gene activation. However, the underlying rules are ...
Novel transcription mechanisms used by dendritic cells in the tumor immune microenvironment
Interferon is essential for eliciting adaptive immunity against cancer cells. Type I interferon (IFNI) activates proinflammatory responses in dendritic cells (DCs) and this promotes specific anti-tumor T cell responses. ...
Equivariant graph neural networks in drug discover: from property prediction to molecule generation
Advancements in machine learning have revolutionized various aspects of drug discovery, from molecular property prediction to de novo design. This thesis presents a comprehensive exploration of equivariant graph neural ...
When P. falciparum meets the brain microvasculature: a 3D blood-brain barrier model to study cerebral malaria
La alteración de la barrera hematoencefálica está relacionada con la malaria cerebral, una complicación de la infección por Plasmodium falciparum asociada con la acumulación del parásito en los vasos sanguíneos cerebrales. ...
Machine learning methods of property prediction in drug discovery
Molecular properties are highly important in drug discovery with binding affinity being crucial for selecting hit and lead candidates. Existing machine learning models often lack speed for large-scale screening or lack ...
Silence speaks volumes a fine-frained analysis of pause production reveals group differences on the spectrum of cognitive decline
Previous evidence suggests that increased pause production in spontaneous speech can indicate cognitive decline in Alzheimer’s disease (AD), and that this may depend on the linguistic context of the pause, such as syntactic ...
Turismo transmedia. Análisis, evaluación y caracterización de experiencias transmedia para el diseño de nuevos espacios turísticos
Esta tesis tiene como objeto de estudio el efecto de las narrativas transmedia en la experiencia turística y su capacidad de diseñar nuevos espacios turísticos en un contexto de convergencia cultural y reconfiguración del ...
Sostenibilidad de los medios de comunicación investigación conceptual y operacional sobre la relevancia y el engagement
La sostenibilidad económica de los medios de comunicación es una prioridad para las sociedades democráticas. Ahora bien, en un entorno digital de alta competencia, es un hecho establecido que, por un lado, los medios han ...
