Now showing items 85-104 of 112
Chico Julià, Berta (Date of defense: 2009-02-19)
La DM 2 és una malaltia multifactorial i multigènica. Aquest fet condueix a l'estudi de molts gens i proteïnes susceptibles d'estar implicades amb la DM 2. Algunes d'aquestes proteïnes i gens estan associats a un estat ...
Oliveras Ferrarós, Cristina (Date of defense: 2013-06-21)
The aim of this doctoral thesis was to unravel mechanisms underlying primary resistance to trastuzumab regarding a putative new breast cancer subtype with mixed basal & ErbB2+ molecular features. Using the JIMT-1 breast ...
Jurado Bruggeman, Diego (Date of defense: 2023-03-16)
Introduction Different types of dose calculation algorithms for external beam radiation therapy with MV photons coexist nowadays. The oldest ones are convolution/superposition (C/S), which consider all media as water of ...
Mateo Otero, Yentel (Date of defense: 2023-06-13)
For many years, reproductive outcomes were considered as being solely determined by the genome of oocytes and sperm. Yet, in the last decades, many other female and male factors have also been found to be relevant. Focusing ...
Marti Serrano, Elisabet (Date of defense: 2014-03-07)
The overuse of antibiotics has led to the selection of resistant strains. This thesis investigated the occurrence of antibiotic resistance genes (ARGs) in aquatic microbial communities influenced by anthropogenic activities. ...
Balmaña Esteban, Meritxell (Date of defense: 2016-07-07)
Cancer is one of the leading causes of death worldwide. Pancreatic ductal adenocarcinoma (PDAC) is characterized by high intrinsic aggressiveness and late diagnosis, causing poor prognosis and resulting in the lowest ...
Font i Sadurní, Josep (Date of defense: 2006-06-02)
Utilitzant temperatura i pressió com a agents desnaturalitzants s'ha explorat la contribució a l'estabilitat de diferents residus del principal nucli hidrofòbic de la RNasa A. Aquests resutats suggereixen que el principal ...
Fernández Hernández, Maria Victoria (Date of defense: 2012-11-28)
The conservation of species relies on a deep knowledge of biology of the species concerned, as well as on the identification of reproductively isolated units, which are genetically different from one other (genetic stocks). ...
Vicens Bordas, Jordi (Date of defense: 2021-06-16)
The physical demands (high-intensity running and sprinting) of football match-play place footballers at increased risk of hamstring injuries. Some of the negative effects of a hamstring injury such as neuromuscular ...
Delgado Bermúdez, Ariadna (Date of defense: 2022-07-28)
The spermatozoon is a highly specialised cell that travels along the female reproductive tract to deliver its genetic information into the oocyte. During this journey, the interaction with the varying environment is crucial ...
Recuero Cobos, Sandra (Date of defense: 2022-04-01)
In Spain, as well as in the rest of Europe, livestock farming represents a substantial part of economy; thus, it is necessary to ensure an optimal breeding of the main farm animals, including swine and cattle. In order to ...
Gonzalez Montes, Yolanda (Date of defense: 2024-04-12)
Multiple myeloma (MM) remains an incurable disease despite the incorporation of new therapies. The natural history of disease is of the relapse following treatments due to the re-emergence of the tumour from residual disease ...
Coll Constans, M. Gràcia (Date of defense: 2000-03-31)
Bovine pancreatic ribonuclease A (RNase A, EC 3.1.27.5) has been extensively studied from the structural, mechanistic and functional points of view. Within the protein folding context, it constitutes a good ...
Bosch i Grau, Montserrat (Date of defense: 2003-12-18)
Amb la finalitat d'aprofundir en les bases moleculars de la citotoxicitat de les ribonucleases pancreàtiques, es van construir variants derivades de l'HP-RNasa seguint dues estratègies. En la primera, es van generar variants ...
Ribó i Panosa, Marc (Date of defense: 1994-12-16)
The answer to whether or not, human pancreatic ribonuclease may have a diagnostic value as a serum marker of pancreatic disease, depend upon the specific detection of ribonucleases originated in pancreas amogn those ...
Bassagañas i Puigdemont, Sònia (Date of defense: 2014-12-03)
Changes in the expression of Lewis-type glycan antigens, especially a predominance of sialyl-Lewis x (SLex) structure, and the glycosyltransferases involved in its synthesis, correlate with pancreatic cancer invasive and ...
Díaz Roldán, Ferran (Date of defense: 2023-07-03)
Childhood obesity is one of the most important public health problems and is associated with cardiometabolic risk factors (CMR). Low-grade inflammation plays a prominent role in the development of cardiometabolic alterations ...
Viñolas Vergés, Estel (Date of defense: 2023-07-27)
Male fertilising capacity has traditionally been predicted by the assessment of sperm concentration, motility and morphology. During the last few decades, however, research has been particularly focused on the analysis of ...
Arribas Bosacoma, Raquel (Date of defense: 2009-07-22)
Es presenta el model atòmic a 4.5 Å de DnaB, la principal helicasa replicativa bacteriana, d'Aquifex aeolicus. És un anell hexamèric de 100 Å d'amplada i 80 Å d'alçada amb dues capes de simetria diferenciada, la dels dominis ...
Pérez Garay, Marta (Date of defense: 2011-02-07)
Este trabajo demuestra que los genes que codifican para los enzimas beta-galactosido alfa-2,3-sialiltransferasa 3 (ST3Gal III), y en menor medida beta-galactosido alfa-2,3-sialiltransferasa 4 (ST3Gal IV), están directamente ...