Departament de Biologia: Enviaments recents
Ara mostrant els elements 61-80 de 112
Estudis cinètics i estructurals de la trans inteïna Npu DnaE de "Nostoc punctiforme"
Les inteïnes són dominis proteics que mitjançant un procés de tall i unió s’autoescindeixen de la cadena polipeptídica precursora i catalitzen la unió de les seqüències flanquejants (exteïnes) mitjançant un enllaç peptídic. ...
Regulation and function of silayltransferases in pancreatic cancer
Changes in the expression of Lewis-type glycan antigens, especially a predominance of sialyl-Lewis x (SLex) structure, and the glycosyltransferases involved in its synthesis, correlate with pancreatic cancer invasive and ...
Anàlisi de la vehiculització de compostos metàl·lics com a agents antitumorals i de la família HER-EGF en la resistència als tractaments oncològics
Most current chemotherapeutic agents are of limited use due to their side effects and the resistance to treatment that tumour cells develop. In this thesis, we have contributed to the knowledge of these limitations through ...
Molecular mechanism of PE5-induced cytotoxicity and generation of new cytotoxic nuclear-directed
Cytotoxic ribonucleases are promising agents to be used in the treatment of cancer. Our group previously described a cytotoxic human pancreatic ribonuclease variant, named PE5, which carries a nuclear localization signal. ...
In vitro production of porcine embryos. New insights into optimization of culture media with relevance to sex ratio purposes
This thesis is about challenges that currently concern in vitro production (IVP), sex determination procedures and sex-related survival of in vitro-produced porcine embryos. Specifically, the current thesis develops a new ...
Vitrification of in vitro produced porcine blastocysts: the effects of culture medium and antioxidants
In the present Thesis, we observed that vitrifying-warming porcine embryos had detrimental effects. Indeed, vitrification and warming were seen to reduce developmental ability and quality of in vitro produced porcine ...
Caracterització de determinants estructurals de propietats especials de la ribonucleasa pancreàtica humana
Ribonucleases are promising candidates for use in anticancer therapy. There are different ways to endow an RNase with antitumor properties. Targeting the enzyme to the cell nucleus is a potential approach. PE5 is a variant ...
Nous mecanismes de resistència primària al trastuzumab (Herceptin): bases moleculars per a la determinació d'un nou subtipus de càncer de mama (Basal/ErbB2+)
The aim of this doctoral thesis was to unravel mechanisms underlying primary resistance to trastuzumab regarding a putative new breast cancer subtype with mixed basal & ErbB2+ molecular features. Using the JIMT-1 breast ...
Phylogeographical analysis of two aristed shrimps, Aristeus antennatus and Aristaemorpha foliacea (Crustacea: Aristeidae), with implications for resource conservation
The conservation of species relies on a deep knowledge of biology of the species concerned, as well as on the identification of reproductively isolated units, which are genetically different from one other (genetic stocks). ...
El Inhibidor de carboxipeptidasa de patata (PCI): un antagonista del EGF con actividad antitumoral
In this work we report that potato carboxypeptidase inhibitor suppresses the growth of several human and mouse pancreatic adenocarcinoma cell lines. The inhibitor also reduces the growth of solid tumors obtained by ...
Purificació, caracterització i clonatge de la ribonucleasa de pàncreas humà
The answer to whether or not, human pancreatic ribonuclease may have a diagnostic value as a serum marker of pancreatic disease, depend upon the specific detection of ribonucleases originated in pancreas amogn those ...
Producció i caracterització de variants de la regió C-terminal de la ribonucleasa A. Importància d'aquesta regió sobre l'estabilitat de l'enzim
Bovine pancreatic ribonuclease A (RNase A, EC 3.1.27.5) has been extensively studied from the structural, mechanistic and functional points of view. Within the protein folding context, it constitutes a good ...
Moléculas séricas relacionadas con la fisiopatología del adenocarcinoma pancreático como posibles marcadores tumorales
Serum levels of several molecules associated to pancreatic adenocarcinoma (PDAC) pathophysiology are evaluated in this work, in order to determine their diagnostic value, distinguishing between PDAC patients and healthy ...
Descripció i quantificació de la microbiota intestinal associada al càncer colorectal
Colorectal Cancer is the main type of cancer in Spain. Up to 90% of the cases are sporadic in nature and its aetiology is still unclear. It is supposed to be a multi-factorial disease, where factors play an important role ...
Estudi de les anomalies cromosòmiques detectades prenatalment i postnatalment per mètodes citogenètics i anàlisi de la contribució dels diferents mètodes de cribratge en la detecció de les anomalies prenatals. Hospital Universitari Dr. Josep Trueta, període 1999-2009
Chromosome abnormalities are one of the most important causes of congenital disorders. The main goal of this research is to give a broad view of the use and evolution of prenatal and postnatal cytogenetic diagnosis in ...
A molecular approach on sperm changes during epididymal maturation, ejaculation and in vitro capacitation of boar spermatozoa
Mammalian spermatozoa acquire functionality during epididymal maturation and ability to penetrate and fertilize the oocyte during capacitation. Sperm quality results indicated that both epididymal maturation and ejaculation ...
Estructura poblacional y demografía genética en poblaciones de trucha común (Salmo trutta) del Pirineo catalán
In the present study an amplification and genotyping system for 9 microsatellite loci has been developed and used to genotype brown trout (Salmo trutta) individuals. This system has allowed, on one hand, to efficiently ...
Glycan alterations of serum proteins as tumour markers. Prostate-specific antigen in prostate cancer and acute-phase proteins in pancreatic cancer
Els pacients amb càncer presenten una taxa de supervivència superior si es diagnostiquen a estadis inicials, per la qual cosa és indispensable disposar de marcadors tumorals adequats. Glicoformes de proteïnes específiques ...
Variabilitat genètica i estructura poblacional en tres espècies de la família Scombridae, Sarda sarda, Thunnus alalunga i Thunnus thynnus, basada en la regió control del DNA mitocondrial
Aquest treball es centra en el coneixement de l'estructura poblacional de tres espècies piscícoles de la família Scombridae, el bonítol (Sarda sarda), la bacora (Thunnus alalunga) i la tonyina (Thunnus thynnus) en la seva ...
Role of alpha 2,3-sialyltransferases ST3Gal III and ST3Gal IV in pancreatic ductal adenocarcinoma
Este trabajo demuestra que los genes que codifican para los enzimas beta-galactosido alfa-2,3-sialiltransferasa 3 (ST3Gal III), y en menor medida beta-galactosido alfa-2,3-sialiltransferasa 4 (ST3Gal IV), están directamente ...
