Rodríguez Sánchez, Maria de los Ángeles (Date of defense: 2019-11-22)
Las proteínas insulator son componentes esenciales de la organización tridimensional de la cromatina ya que son capaces de establecer interacciones entre regiones distantes de la mediante su capacidad ...
Guberović, Iva (Date of defense: 2021-10-01)
The histone variant macroH2A is the only structural chromatin component containing a macrodomain. In vertebrates, two genes and one event of alternative splicing give rise to three macroH2A proteins ...
Vicioso Mantis, Marta (Date of defense: 2022-09-27)
The thesis objectives resulted from previous work from Dr Martínez-Balbás lab that characterized the cooperation between TGFβ and JMJD3 to regulate transcription at enhancers, promoters, and gene ...
Escudero Ferruz, Paula (Date of defense: 2021-06-28)
This work is focused on Barrier-to-Autointegration Factor (BAF) protein. BAF is a nuclear envelope (NE) component that binds chromatin and is required for NE reassembly (NER) at mitosis exit. Previous ...
Deniz, Ozgen (Date of defense: 2014-05-06)
The nucleosome is the fundamental structural unit of DNA compaction in eukaryotic cells and is formed by the wrapping of 147 bp double stranded DNA around a histone octamer. Nucleosome organization plays ...
Bujosa Rodriguez, Paula (Date of defense: 2023-09-27)
[eng] Linker histones are essential proteins involved in higher-order chromatin structures and architectural functions. However, their roles extend beyond structure, encompassing various chromatin ...
Salinas Pena, Mónica (Date of defense: 2023-09-20)
[eng] The histone H1 family comprises up to seven members in human somatic cells. However, H1 studies have been limited by the lack of specific ChIP-grade antibodies. Here, we have mapped six endogenous ...
Dyson Coral, Silvia (Date of defense: 2021-12-14)
Topoisomerase II often produces DNA knots and catenates when its DNA strand passage activity equilibrates the topology of intracellular DNA. However, these DNA entanglements are detrimental for the ...
Flores Guri, Oscar (Date of defense: 2014-06-10)
This thesis presents a broad study of the chromatin structure and function with special focus in the nucleosome organization. More specifically, it includes three different but complementary perspectives: ...
Ramos Rodríguez, Mireia (Date of defense: 2020-11-06)
Type 1 Diabetes (T1D) is a celltargeted autoimmune disease, leading to a reduction in pancreatic cell mass that renders patients insulindependent for life. In early stages of the disease, cells ...