Universitat de Barcelona
La Universitat de Barcelona és la universitat pública principal de Catalunya, amb el nombre més gran d’estudiants i l’oferta formativa més àmplia i completa. A més, és el principal centre de recerca universitari de l’Estat i un dels més importants d’Europa, tant per nombre de programes de recerca com per l’excel·lència assolida en aquest terreny.Estretament vinculada a la història de Barcelona i de Catalunya, la UB combina els valors de la tradició amb el fet de ser una institució innovadora i d’excel·lència en l’àmbit docent, i és una universitat urbana, oberta i cosmopolita com la mateixa ciutat de Barcelona.Us convidem a conèixer la Universitat de Barcelona!
Si sou doctor o doctora de la Universitat de Barcelona i voleu publicar la vostra tesi a TDX, contacteu amb tdx@ub.edu. Per a més informació consulteu les preguntes més freqüents
[eng] TGF-ꞵ signaling is key for many biological processes as embryo development, tissue homeostasis and immune system regulation. When altered, this pathway can lead to diseases such as cancer, fibrosis and rare syndromes. ...
[eng] In this thesis, our focus was on unraveling how Caenorhabditis elegans samples its environment in the absence of gradients and food resources. We analyzed data from a relocation experiment in which individual worms, ...
[eng] During radiotherapy (RT) some healthy tissues are irradiated inevitably causing side effects, without being able to predict nowadays which patients will develop this toxicity. To date, the biomarker with the best ...
[spa] La Fibrosis Quística (FQ) es una enfermedad autosómica recesiva causada por variantes patogénicas en el gen Cystic Fibrosis Transmembrane Regulator (CFTR). La proteína resultante, también llamada CFTR, se expresa en ...
[eng] Anti-cancer therapies are based on the infliction of damage or stress to cancer cells, with the aim of triggering cell death. In practice, a fraction of cancer cells often evades cell death and enters a state of cell ...
[spa] Esta tesis investiga la asociación de la microbiota intestinal con el ictus isquémico. Se reclutaron un total de 340 pacientes con ictus, de los cuales se analizó una muestra fecal para obtener un perfil taxonómico ...
[eng] Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are aggressive soft-tissue sarcomas. They usually appear in the clinical context of Neurofibromatosis type 1 (NF1), however, they also occur at a low frequency in the ...
[eng] Cytoplasmic Polyadenylation Element Binding proteins (CPEBs) are a family of RNA-binding proteins that regulate cytoplasmic changes in poly(A) tail lengh and therefore mRNA-specific stability and translation. Since ...
[eng] DYRK1A is a kinase that is expressed in virtually all tissues and cell types and is implicated in human diseases. Several studies indicate that DYRK1A is a dose-dependent gene with a prevalent function in brain ...
[eng] Mutations exhibit an uneven distribution across the human genome, with a regional mutation density (RMD) influenced by chromatin landscapes and replication timing. While there is a good understanding of this variation, ...
[eng] Our understanding of the transcriptional control of cellular identity is rapidly emerging. Mediator complex enriches at active enhancers, forms a protein bridge to target genes, and recruits RNA Polymerase II ...
[eng] Common sexually transmitted infections like gonorrhea, Chlamydia, syphilis, and trichomoniasis are the leading cause of morbidity in developing countries. Adolescents and young women have the highest rates of STIs ...
[eng] Rett syndrome (RTT) is a severe neurodevelopmental disorder characterized by a regression in acquired skills, such as purposeful hand use and language, after an apparently normal early development. RTT affects ...
[eng] Precision medicine aims to provide personalized patient care using genetic data. However, interpreting the phenotypic consequences of genetic variants remains a bottleneck in both clinical and research settings. ...
[eng] The application of mechanical force to the nucleus has been recently shown to regulate important functions, including nucleocytoplasmic transport (NCT), chromatin organization, and gene expression. However, how ...
[eng] Fungal infections pose a serious health threat, affecting >1,000 million people and causing ~1.5 million deaths each year. The problem is growing due to insufficient diagnostic and therapeutic options, increased ...
[eng] Advances in capturing technologies have yielded a massive production of large-scale molecular data that describe different aspects of cellular functioning. These data are often modeled as networks, in which nodes are ...
[eng] Proteins are fundamental building blocks of life, and understanding their structure and function is crucial for many fields of science, from drug discovery to bioengineering. Traditional experimental methods for ...
[eng] Lysinuric Protein Intolerance (LPI) is a rare autosomal recessive disorder caused by mutations in the SLC7A7 gene, which encodes the y+LAT1 transporter. LPI presents a pleiotropic phenotype that varies among patients, ...
[eng] Substance use disorders (SUDs) are psychiatric disorders characterized by a recurring desire to continue taking a substance regardless of its destructive consequences. The etiology of SUDs is complex and multifactorial, ...
