Facultat de Biologia: Enviaments recents
Ara mostrant els elements 181-200 de 253
Identification of novel mechanisms in human breast cancer lung metastasis and chemoresistance
Breast Cancer (BC) is one of the major causes of cancer deaths in women. BC is a heterogeneous disease, and within the heterogeneity of the tumor, Tumor-Initiating Cells (TICs) have been reported as important drivers in ...
Environment matters : the impact of urea and macromolecular crowding on proteins
This work aims to analytically understand the impact of two diametric opposite environments on protein structure and dynamics and compared them to the most common solvent on earth: water. The first environment is a popular ...
Caracterización de las alteraciones estructurales y funcionales de la corteza cerebral de ratones mutantes de pérdida y ganancia de función de DYRK1A
DYRK1A es un gen del cromosoma 21 humano que codifica para una proteína quinasa constitutivamente activa que fosforila a sustratos que son clave en el desarrollo del cerebro. La proteína DYRK1A regula el crecimiento del ...
Role of Mfn2 in Macrophage Inflammatory Responses
Mitochondria are well known for their role as bioenergetic and biosynthetic organelles. Recently, they also have emerged as one of the main regulators of innate immune responses, mostly for its ability to modulate several ...
Metabolisme dels Esfingolípids. Noves metodologies i efecte sobre l´autofàgia
Els esfingolípids són lípids complexes derivats de l’esfingosina que a més de servir de base estructural de les membranes cel·lulars, regulen múltiples vies de senyalització, com per exemple l’autofàgia. Entre tots els ...
Análisis de los perfiles de expresión de microRNAs en cáncer de mama y de la implicación de la familia miR-200 en metástasis
Esta tesis consiste en el estudio de la regulación por microRNAs del proceso de metástasis de carcinomas ductales invasivos de mama. Hemos encontrado una expresión alterada de varios microRNAs en muestras tumorales, ...
Implementation of a novel analytical framework for large-scale genetic data. Extending the genetic architecture of type 2 diabetes beyond common variants
The major landmark in modern genomic and biological research has been the first survey of the entire human genome. On June 2000 the staging of Bill Clinton along with Craig Venter and Francis Collins extolled how genome ...
Parmbsc1: Parameterization and Validation of a new State-of-the-art Force Field for DNA Simulations
Classical force fields are the core of classical simulations, particularly of molecular dynamics (MD), a technique that is changing our view on the structure, flexibility and function of biological macromolecules. Originated ...
Impacts of climate and drought on tree radial growth in Neotropical dry forests: Scaling up from short to long time-scales = Impactos del clima y las sequías en el crecimiento radial de los árboles en los bosques secos Neotropicales: Evaluación de sus efectos a diferentes escalas temporales
This thesis analyzed the dynamics of tree radial growth at different time-scales in relation to climate and drought in two tropical dry forests (TDFs) from Colombia (Tuluá) and Bolivia (INPA). The specific objectives were: ...
Evolutionay demography of the Balearic Wall lizard (Podarcis lilfordi) = La demografia evolutiva de la Sargantana Balear (Podarcis lilfordi)
Many topics in ecology and evolution are currently being studied under the framework of eco- evolutionary dynamics that is to say integrating genetic, ecological and demographic data. Here, I have focused my investigations ...
Identification and functional analysis of molecular mechanisms involved in the latency of ER positive breast cancer
Breast cancer is the most frequently diagnosed cancer and remains the second leading cause of death among women in Europe and United States. In this malignancy, metastasis remains to be an incurable condition, and therefore ...
Papel del colágeno VI en la homeostasis del músculo esquelético y tejido adiposo: implicaciones en la patofisiología de las distrofias musculares
El colágeno VI es una proteína de la matriz extracelular cuyos defectos conducen a una variedad de trastornos musculares en humanos caracterizados por una debilidad muscular entre otros múltiples síntomas. Tanto el colágeno ...
Deficiencia de 2-metil-3-hidroxibutiril-CoA deshidrogenasa (MHBD o HSD10) e implicaciones en la enfermedad de Alzheimer
Esta tesis se basa en diagnóstico de pacientes con deficiencia de 2 metil 3 hidroxibutiril CoA deshidrogenasa (MHBD o HSD10) y en el estudio de la fisiopatología de esta enfermedad y de su implicación en la Enfermedad de ...
Caracterización molecular del reflejo inflamatorio y modulación de la respuesta inmune frente a infecciones en peces
El mantenimiento de la homeostasis del sistema inmune innato es fundamental, ya que éste debe mantener una respuesta equilibrada frente a los patógenos. En mamíferos, uno de los mecanismos por el cual se mantiene la ...
Essential functions of Cpeb4 in tissue homeostasis
The Cytoplasmic Polyadenylation Element Binding (CPEB)-family of RNA-binding proteins is composed of four paralogs in mammals, CPEB1-4. The CPEBs control the translation of the targeted mRNAs by modulating the length of ...
Morphological structure and biodiversity in fish assemblages = Estructura morfològica i biodiversitat en comunitats de peixos
The study of morphology of organisms has become a widely extended scientific discipline since the beginning of the 20th century, when the scientific community began to establish direct relationships between the anatomical ...
Biodiversity patterns of coralligenous outcrops over broad spatial and temporal scales in the NW Mediterranean Sea: baseline data for conservation
Increasing anthropogenic pressures and its effects on marine ecosystems urge enhanced knowledge and understanding of the current state of marine biodiversity. This baseline information is pivotal to establish the actual ...
Biological applications of discrete molecular dynamics
Sequence, structure and dynamics are an indivisible tandem to understand protein function. Luckily, evolution imposed a hierarchical rational between that facilitates the analysis: dynamics are encoded in the structure, ...
Identification and characterization of non-coding genomic variations associated to cancer diseases
The genetic and molecular bases of most of the human diseases have become one of the main goals of the human biology in the last decades. To be able to unveil the genetic variations and the affected cellular processes ...
Network biology identifies novel apoptosis-related proteins and synergistic drug combinations in breast cancer
Breast cancer is a very heterogeneous disease with a poor prognostic outcome, largely due to its resistance to current cancer therapies. The balance between cell proliferation and apoptosis plays a critical role in determining ...
