Facultat de Biologia: Recent submissions
Now showing items 181-200 of 236
Biological applications of discrete molecular dynamics
Sequence, structure and dynamics are an indivisible tandem to understand protein function. Luckily, evolution imposed a hierarchical rational between that facilitates the analysis: dynamics are encoded in the structure, ...
Identification and characterization of non-coding genomic variations associated to cancer diseases
The genetic and molecular bases of most of the human diseases have become one of the main goals of the human biology in the last decades. To be able to unveil the genetic variations and the affected cellular processes ...
Network biology identifies novel apoptosis-related proteins and synergistic drug combinations in breast cancer
Breast cancer is a very heterogeneous disease with a poor prognostic outcome, largely due to its resistance to current cancer therapies. The balance between cell proliferation and apoptosis plays a critical role in determining ...
Change agents: sea urchin regulation and state shifts in Mediterranean macrophyte systems = Agents de canvi: el control de les garotes i els canvis d'estat en els ecosistemes de macròfits de la Mediterrània
Macrophyte systems are globally vulnerable to overgrazing, often shifting precipitously to functionally poorer alternative stable states triggered by herbivore population outbreaks. Sea urchin herbivory can cause shifts ...
Benthic communities' response to different trawling impact levels: generalization towards developing a Mediterranean model = Resposta de les comunitats bentòniques a diferents nivells d’impacte de pesca d’arrossegament: generalització per al desenvolupament d’un model mediterrani
Fisheries management has definitively embraced the Ecosystem Approach to Fisheries (EAF) philosophy and new management policies are incorporating integrative measures that take into account not only target species but also ...
Distribution and dynamics of multiple components of plant diversity in a high mountain area: the Ordesa-Monte Perdido National Park = Distribución y dinámica temporal de los diferentes componentes de la diversidad vegetal en la alta montaña: el Parque Nacional de Ordesa y Monte Perdido
The aim of this thesis was to explore the distribution of the taxonomic, phylogenetic and functional components of plant diversity in high mountains, and to show how different components of diversity have responded to ...
Dental morphology and dental wear as dietary and ecological indicators: sexual and inter-group differences in traditional human populations
Sexual division of labour involving the use of teeth in non-masticatory activities in the Tigara population form Point Hope did not affect the wear of the upper and lower first molars and, therefore, food chewing was the ...
Identification of suppressors of the constitutive photomorphogenic phenotype of pifq: from chloroplasts to rhythmic growth
Plants germinated in the dark under the soil surface, undergo skotomorphogenic development. Once they emerge from the soil surface perceive light for the first time. Then, seedlings switch from skotomorphogenic to ...
Canvis antropomètrics i bioquímics en l'obesitat mòrbida després de la cirurgia bariàtrica: influència de les comorbiditats
INTRODUCCIÓ: Actualment el bypass gàstric en Y-de-Roux és la tècnica més freqüent portada a terme en l’àmbit internacional en què, en ser de tipus mixta, es produeix una combinació dels elements restrictius i de malabsorció. ...
Estudio del sistema kisspeptina y su papel en el inicio de la pubertad de la lubina europea (Dicentrarchus labrax): Efecto de la restricción calórica en machos
En esta tesis doctoral se estudia el efecto de una dieta de restricción calórica de mantenimiento a largo plazo (14 meses), en machos de lubina prepúberes, sobre el inicio y desarrollo de la pubertad. Para ello se consideró ...
Evolution, diversification and ecology of a clade of strictly subterranean beetles (Troglocharinus, Family Leiodidae)
The general aim of this dissertation is to investigate the evolution, the diversification and some ecological traits of the species of the strictly subterranean genus Troglocharinus Reitter, 1908. The genus Troglocharinus ...
Responses to environmental xenobiotics: from endocrine disruption to lipid homeostasis imbalance
Many chemicals are continuously entering into the aquatic environment, as a result of their widespread use, disposal and accidental release. Several of these xenobiotics may disrupt reproductive functions of both vertebrates ...
Generació d'un model cel·lular osteoblàstic i aproximacions terapèutiques per a la malaltia de Gaucher
La malaltia de Gaucher (GD) forma part d'un conjunt de malalties que es coneixen amb el nom de "malalties d'acumulació lisosómica". La GD n'és la més prevalent i en la majoria de casos és causada per mutacions en el gen ...
Connecting biodiversity and biogeochemical role by microbial metagenomics
The main objective of this PhD dissertation was to unveil the links between biogeochemistry and microbial diversity using metagenomics functional potential as a proxy to connect a mechanistic perspective with whole-system ...
Caracterización molecular y búsqueda de causas genéticas del cáncer colorrectal hereditario no polipósico
La presente tesis doctoral consta de 4 proyectos independientes centrados en el estudio de las causas genéticas del cáncer colorrectal (CCR) hereditario: A) Estudio de una variante común (rs2075786) en el gen de la ...
SP Transcription factors in psychotic disorders
Psychotic disorders including bipolar disorder and schizophrenia are a leading cause of disability across the world but the underlying pathophysiological mechanisms remain poorly understood. Available treatments are ...
Combinació de tècniques citogenètiques en la leucèmia limfàtica crònica: estudi de l'heterogeneïtat dels pacients i aplicabilitat a la pràctica clínica
Un dels factors pronòstics més importants en la leucèmia limfàtica crònica (LLC) són les categories de risc citogenètic, basades en la detecció de del(13q), trisomia 12, del(11q) i del(17p) per hibridació in situ fluorescent ...
Enforcing secondary and tertiary structure for crystallographic phasing. Developing ARCIMBOLDO and BORGES
ARCIMBOLDO is an ab initio phasing method for macromolecular crystallographic X-ray diffraction data, which combines location of model fragments such as polyalanine α- helices with the program PHASER and density modification ...
Plant diversity and vegetation of the Andean Páramo
The páramo is a high mountain ecosystem that includes the natural and semi-natural habitats located between the montane treeline and the permanent snowline in the humid Northern Andes. Given its recent origin and continental ...
Modulación de las propiedades migratorias de las células de la glia envolvente
Las células de la glía envolvente olfatoria surgen hace algunos años como una estrategia prometedora para reparar la médula espinal lesionada. Sin embargo, diversas moléculas inhibitorias están presentes durante largo ...
