Facultat de Biologia: Envíos recientes
Mostrando ítems 41-60 de 236
Desarrollo de herramientas para el análisis y predicción patogénica de las variantes missense de ATM en el entorno clínico
[spa] Establecer la naturaleza patogénica de las variantes de secuencia en ATM, un gen asociado con el cáncer de mama y otros cánceres hereditarios, es crucial para brindar una atención adecuada a los pacientes. Sin embargo, ...
New therapeutic approaches to modulate metabolic alterations in the cardiovascular system. In vivo studies
[eng] BACKGROUND: Low-density lipoprotein receptor-related protein 1 (LRP1) plays a key role in fatty acid metabolism and glucose homeostasis. In the context of dyslipidemia, LRP1 is positively regulated in the heart. The ...
Contribución al estudio de la fauna bentónica del litoral de Blanes : Invertebrados neríticos con especial dedicación al grupo de las esponjas
[spa] Desde que en el siglo pasado empezaron a tomarse en consideración los entonces incipientes estudios de Biología Marina para racionalizar la pesca de la época, una de las primeras preocupaciones fue la pesca al arrastre, ...
From the discovery of epistatic events in Type 2 Diabetes Mellitus to the study of related gene expression regulatory variation
[eng] One of the major and most challenging goals of Biomedicine during the last centuries has been the study of the human biological mechanisms, and its relation with traits and diseases. Particularly, in the case of ...
Estudio de biomarcadores en los defectos de la fosforilación oxidativa mitocondrial y en las deficiencias de coenzima CoQ10
[spa] El objetivo general de este trabajo de tesis doctoral ha sido progresar en el desarrollo de biomarcadores para el estudio de pacientes con enfermedades mitocondriales. Los objetivos concretos han sido los ...
Nucleic acid and small molecule recognition by Smad transcription factors and co-factors
[eng] Tumour progression largely depends on the signalling networks that direct cell viability, growth and dissemination (metastasis). Transforming growth factor beta (TGF-β) and Bone Morphogenetic Protein (BMP) are cytokines ...
Evaluation of immunebiomarkers in Lung Cancer
[eng] Treatment landscape in early-stage NSCLC is rapidly changing after approval of anti-PD-1/PD-L1 in the neoadjuvant and adjuvant settings, respectively. However, biomarkers for patient selection, to predict response ...
Sistema de paneles virtuales de genes para genómica clínica basado en NGS
[spa] El diagnóstico de enfermedades humanas originadas a causa de variantes y mutaciones en el ADN de cada persona está experimentando un cambio de paradigma, desde la aproximación genética tradicional hacia una que ...
Molecular characterization of High Risk Neuroblastoma. Potential biomarkers for high-risk neuroblastoma classification
[eng] BACKGROUND: High-risk neuroblastoma (NB) represents a heterogeneous group of tumors, whereby patients can display response to treatment and long-term outcome or develop early progressive, chemoresistant disease with ...
Network-driven strategies to integrate and exploit biomedical data
[eng] In the quest for understanding complex biological systems, the scientific community has been delving into protein, chemical and disease biology, populating biomedical databases with a wealth of data and knowledge. ...
Application of Next Generation Sequencing to Study the Genetics of Idiopathic Neonatal Arterial Ischemic Stroke
[eng] Neonatal arterial ischemic stroke (NAIS) is a cerebrovascular disease that shows a focal disruption of cerebral blood flow due to artery obstruction. Due to its early onset, it can cause long-lasting outcomes such ...
Biodiversity assessment of marine benthic communities with COI metabarcoding: methods and applications
[eng] Ecosystem biomonitoring is crucial for proper management of natural communities during the Anthropocene era. With the advent of new sequencing technologies, DNA metabarcoding has been proposed as a game-changing tool ...
Pharmaceutical development of nanosystems for the delivery of drugs in epidermis and hair follicles, skin biodistribution studies
[eng] Different transdermal drug delivery platforms have been developed for epidermal and follicular targeting. Nanoformulations have been developed, optimised and physicochemically characterised with complementary techniques. ...
Protective role of polyethylene glycol 35 against hepatic cold and warm ischemia
Steatotic livers are considerably more prone to IRI, in which turn, it is known to impair mitochondrial function. Our working hypothesis lies on the fact that impaired mitochondrial function and reduced protection against ...
Development and application of computer-aided strategies for virtual screening and hit-to-lead
The incremental application of supercomputers to offer solutions to complex problems has motivated the usage of computational modeling tools in drug design pipelines. Specifically, small low-affinity compounds are modified ...
Characterization of the molecular mechanisms used by JmjC-lysine demethylases to regulate gene expression
The thesis objectives resulted from previous work from Dr Martínez-Balbás lab that characterized the cooperation between TGFβ and JMJD3 to regulate transcription at enhancers, promoters, and gene bodies.Taking into ...
Modeling and targeting metastatic relapse in colorectal cancer
Colorectal cancer (CRC) kills around 700,000 people worldwide every year. The majority of these deaths are the result of dissemination of the disease to foreign organs. Despite undergoing curative resection of the primary ...
Understanding stochastic and deterministric microbial assembly processes in ephemeral saline lakes
Understanding the mechanisms and processes driving biological com- munities assembly, i.e. determining why a specific community is found under certain circumstances, is one of the fundamental questions in ecology. The ...
Fibroblastic SNAIL1 induces a metastasis-permisive tumor stroma by regulating fibronectin alternative splicing
SNAIL1 is a transcription factor with roles in repression of epithelial genes and enhancement of mesenchymal genes. As such, it plays a key role in Epithelial-to-mesenchymal transition and in fibroblast activation into ...
Refining prognosis capacity and implementing priciples of personalized therapies for Neurofibromatosis Type 2
Neurofibromatosis type 2 (NF2) is an autosomal dominant condition caused by loss of function variants in the NF2 gene. The pathognomonic feature of the disease is the development of bilateral vestibular schwannomas (VS), ...
