Facultat de Biologia: Recent submissions
Now showing items 121-140 of 236
Femoral bone mineral density and rectus femoris phenotype as sarcopenia indicators after a pulmonary rehabilitation protocol in patients with chronic respiratory disease
INTRODUCTION: Patients with chronic respiratory disease (CRDs) have a disorder in muscle structure and function, but their function increases with physical progress and decreases the risk of general and muscular weakness. ...
Understanding the link between chromatin structure, chromosome conformation and gene regulation
Understanding the connection between DNA organization in the nucleus, and cell functioning is one of the most intriguing problems in biology. Although many interdisciplinary efforts have been developed for this aim, the ...
A systematic and comprehensive approach for large-scale genome-wide association studies. Unraveling non-additive inheritance models in age-related diseases
Genome-wide association studies (GWAS) have been proven useful for identifying thousands of associations between genetic variants and human complex diseases and traits. However, the identified loci account for a small ...
Desarrollo de nuevas aproximaciones para el diagnóstico molecular de los síndromes de predisposición hereditaria al cáncer asociados a deficiencia del sistema de reparación de apareamientos erróneos
La función principal del sistema de reparación de apareamientos erróneos (MisMatch Repair, MMR) es corregir los errores principalmente introducidos por las DNA polimerasas durante la replicación del genoma. Las mutaciones ...
Influence of predictable anthropogenic food subsides on seabird´s breeding investment
Recent policies on the ban of fishing discards and the closure of open-air landfills are expected to reduce amount of predictable anthropogenic food subsidies (PAFS) for seabirds. To forecast the ecological consequences ...
Functional characterization of single amino acid variants
Single amino acid variants (SAVs) are one of the main causes of Mendelian disorders, and play an important role in the development of many complex diseases. At the same time, they are the most common kind of variation ...
Molecular mechanisms involved in the cerebral cortex development and their implications in neurodevelopmental disorders
During the process of corticogenesis, cortical radial glial cells (RGs) generate sequentially most of the distinct types of neurons and glial cells that will populate the neocortex. The generation of these cells at the ...
Estudios genéticos masivos en el ictus isquémico: factores de riesgo y pronóstico
El ictus es una enfermedad compleja que afecta al cerebro y al sistema vascular. Esta enfermedad tiene una alta mortalidad, siendo la segunda causa de muerte a nivel mundial y la primera causa de discapacidad en adultos ...
The role of the histone variant macroH2A in the regulation of chromatin architecture
In the eukaryotic cell nucleus, DNA is tightly wrapped around histone complexes, forming a dynamic structure known as chromatin. The nucleosome particle is the basic repeating unit of the chromatin fiber and its protein ...
Tyrosine Hydroxylase Deficiency: Studies in patient samples and in a cellular model
Monoamine Neurotransmitter diseases are a rare group of inherited disorders of metabolism that encompass 12 different genetic defects leading to abnormal dopamine and/or serotonin brain homeostasis. They correspond to ...
Resultados funcionales de la participación de las proteínas insulator en la organización de la cromatina
Las proteínas insulator son componentes esenciales de la organización tridimensional de la cromatina ya que son capaces de establecer interacciones entre regiones distantes de la mediante su capacidad de asociarse a otras ...
Adressing the reliability of data-poor stock assessment methods to provide advice on the status of small-scale fisheries
Small-scale fishers are often identified as key players in the recovery of overexploited fish and invertebrate stocks supplying food for rural people and contributing to achieving healthy marine ecosystems. Stocks harvested ...
Study of the Secundary Neurulation in the chick embryo, a model to understand neural tube defects = Estudio de la neurulación secundaria en el embrión del pollo, un modelo para entender los defectos del tubo neural
Body axis elongation is a hallmark of the vertebrate embryo, which also comprises the morphogenesis of the caudal neural tube (NT). The contribution of bipotential neuromesodermal progenitors (NMPs) to the cranio-caudal ...
Role of DPPA3 in hypoxia and tumour dormancy in cancer
Colorectal cancer (CRC) is a leading cause of death worldwide and tumour recurrence is a frequent complication that arises from minimal residual disease and shows up after a period of clinical dormancy. Slow-cycling cancer ...
Unveiling novel functions of the trascriptional repressor HDAC7 in B lymphocyte development
B lymphopoiesis is the result of several cell lineage choices and differentiation steps whose perturbation leads to B cell malignancies. Cellular transitions for B cell generation have been associated with gene activation ...
Detection of somatic variants from genomic data and their role in neurodegenerative diseases
Somatic mutations are those that arise after the zygote is formed and are therefore inherited by a fraction of the cells of an individual. Their relevance in certain skin diseases has been known for almost half a decade ...
Role of D-fagomine and omega-3 plyunsaturated fatty acids on gut microbia and related metabolic changes in healthy rats and in a model of fat-induced prediabetes
Modern lifestyles in an increasing number of human societies include consuming an excess of saturated fats and refined sugars as well as enjoying microbiologically aseptic environments. Maintaining the appropriate ...
Investigating the role of testis-mitochondiral genes in Drosophila lethal (3) malignant brain tumor
Genetically tractable models such as Drosophila melanogaster may help to identify new approaches to halt malignant growth. During my doctoral thesis, I performed a screen to find mitochondrial genes required for the growth ...
A genome editing based approach to study tumor cell heterogeneity
Colorectal tumors are not homogeneous entities but rather composed of a mixture of cells with different phenotypes, reminiscent of healthy intestinal epithelium cell types. Intestinal epithelium is one of the organs with ...
The role of GCP8 in microtubule nucleation and cell cicle progression
Microtubules (MTs) mediate a range of essential cellular processes including cell division, intracellular transport and organelle positioning, by forming specifically adapted arrays. Assembly, maintenance and remodelling ...
