Universitat de Barcelona
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[eng] This doctoral thesis aims to explore various synthetic methodologies and their corresponding applications in the field of asymmetric catalysis. More specifically, we have focused on the preparation of prochiral ...
Gaucher disease (GD) is one of the most prevalent lysosomal storage diseases.A mutation on gene gba1 generates a misfolded enzyme acid β-glucosidase. Due to this, this enzyme is not properly transported from the endoplasmic ...
Esta tesis presenta una serie de estudios computacionales basados en métodos de estructura electrónica en los que se analizan la anisotropía magnética y las propiedades derivadas de esta en complejos magnéticos candidatos ...
La present Tesi Doctoral descriu tots els esforços dedicats a la síntesi total de la iriomoteolida- 2a, un nou macròlid aïllat per Tsuda i col·laboradors a l’illa d’Iriomote (Japó) l’any 2015. Exhibeix una moderada ...
El VIH-1 segueix essent un dels problemes més greus de la sanitat pública mundial, especialment als països del tercer món. La fase més avançada de la infecció pel VIH és la SIDA (síndrome d’immunodeficiència adquirida). La ...
This thesis deals with the preparation and characterization of novel organic semiconductors based on the carbazole heterocycle for electronic and optoelectronic applications, specifically to be studied as active layers in ...
Sphingolipids (SLs) encompass a large and diverse family of lipids that are essential constituents of cellular membranes. In addition to their structural functions, SLs are also emerging as important signalling molecules ...
Amb l’objectiu d’obtenir materials moleculars amb una o més propietats físiques tals com magnètiques, luminescents i/o quirals en aquest treball s’han obtingut nous compostos de coordinació basats en metalls de transició, ...
La Tesi tracta sobre la preparació i l’ús en catàlisi homogènia asimètrica de lligands fosforats quirals amb àtoms de fòsfor estereogènics. En primer lloc es descriu la preparació i caracterització de lligands monofosforats ...
[eng] Carbohydrates, as the most abundant biomolecules, play a myriad of roles and functions in biological systems. Unlike the building blocks of proteins, amino acids, whose chemical structure can vary significantly, ...
Carbohydrates are one of the most important biochemical molecules due to their role as energetic resource for non-photosynthetic organisms, cell-cell recognition and adhesion, protection of cell membranes of bacteria and ...
The discovery of cisplatin and its successful use as chemotherapeutic agent have encouraged the development of metal-based anticancer molecules. The present doctoral research project includes three different chemistry ...
[eng] In this Thesis, we have explored the applications in cancer diagnosis and therapy of COUPY fluorophores, a new family of compounds based on the coumarin structure and operating in the far-red to near infrared region ...
[eng] This Doctoral Thesis is focused on the synthesis of cyclometallated platinum compounds with different structural modifications rationally designed specifically for biological or optical applications. Specifically, ...
Posar al mercat un nou fàrmac és un procés molt llarg i costós i que comporta un risc econòmic important per una empresa farmacèutica. En canvi, el desenvolupament d'un procediment millorat per a la producció d'un fàrmac ...
Investigacions recents en el camp de la biomedicina han demostrat que les interaccions entre pèptids i macromolècules com ara les proteïnes, modulen i regulen processos biològics importants com la memòria, la resposta a ...
Combining the judiciously designed bis−β-diketone and polypyrazolyl scaffolds with the crystal field effects on the 3d metal ions, this manuscript exposes different methods of selective preparation of new heterometallic ...
One of the main objectives of this thesis was the synthesis of new chelating ligands containing a photochromic unit able to change its conformation upon light irradiation. This isomerization should serve to modify the ...
Matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases involved in the degradation of the extracellular matrix. They make a major contribution to the progression of a vast number of diseases, ...
[eng] The use of supramolecular interactions in catalysis has been widely studied and exploited for the straightforward preparation of the backbones of an array of structurally diverse stereoselective catalysts. In addition ...
