Monlleó Mas, Ester (Date of defense: 2016-11-25)
Gaucher disease (GD) is one of the most prevalent lysosomal storage diseases.A mutation on gene gba1 generates a misfolded enzyme acid β-glucosidase. Due to this, this enzyme is not properly transported ...
Mohammad Jabeen, Irrem Laareb (Date of defense: 2021-09-23)
c-Src is a non-receptor tyrosine kinase that controls numerous cellular signaling pathways. c-Src implication in human cancers was brought into the attention in the 1980s. Since its discovery, ...
Kennington, Stuart (Date of defense: 2020-12-21)
This thesis focuses on the search for new methodologies for the direct, stereoselective and catalytic formation of carbon-carbon bonds through the formation of chiral nickel(II) enolate species and the ...
Lobo Ruiz, Ariadna (Date of defense: 2019-05-10)
Peptides and proteins are essential substances for living organisms, as they can be found in every cell and tissue and are involved in many biological and physiological processes. Given their intrinsic ...
Duran Corbera, Macarena (Date of defense: 2021-09-30)
Investigacions recents en el camp de la biomedicina han demostrat que les interaccions entre pèptids i macromolècules com ara les proteïnes, modulen i regulen processos biològics importants com la ...
Mir Morro, Bartomeu (Date of defense: 2019-11-22)
Given the increasing interest in i-motif structures, obtaining such structures as well as detailed structural information under physiological conditions have become hot topics in the structural biology ...
Agramunt Pi, Jordi (Date of defense: 2019-11-08)
2,2-Disubstituted cyclopent-4-ene-1,3-diones (CPDs), which have been as non-hydrolysable maleimide analogs, have been found to possess an unexpected reactivity with N-terminal cysteines. Whilst maleimides ...
Bellido Muñoz, Marina (Date of defense: 2023-11-03)
[eng] This doctoral thesis aims to explore various synthetic methodologies and their corresponding applications in the field of asymmetric catalysis. More specifically, we have focused on the preparation ...
Pascual i Pérez, Marina (Date of defense: 2023-11-10)
[eng] Multidrug resistant bacteria have grown to be a significant medical concern as a result of decades of excessive antibiotic usage and overuse in human medicine, agriculture, and the animal industry. ...
Bujaldón Carbó, Roger (Date of defense: 2022-11-22)
[eng] The increasing demand on next-generation displays encourages an exhaustive research on the development of new and enhanced semiconductors. Apart from the conventional inorganic materials, organic-based ...