Universitat de Barcelona
Ara mostrant els elements 24-43 de 46
This PhD Thesis pursues the development of novel anti-Alzheimer and antiprotozoal drug candidates upon exploitation of three different novel approaches: Multitarget therapies, Drug repurposing, and Validation of a novel ...
Alzheimer’s disease (AD) is the main neurodegenerative disorder and one of the most important health-care problems worldwide, because of its high prevalence and personal and economic impact. To aggravate this situation, ...
Diabetes represents one of the biggest health challenges of the 21st century. Insulin resistance is the primary defect in the most common form of diabetes, type 2 diabetes mellitus (T2D), and is defined as a failure in the ...
The present thesis is included in the area of Nanomedicine and supramolecular chemistry, focused on the design and preparation of different nano and microtools for delivery, therapy and sensing. Initially, the synthesis ...
En esta Tesis doctoral, se ha puesto a punto una ruta sintética para acceder de manera rápida y eficaz, a compuestos policíclicos tipo “cinturón” que contienen dos dobles enlaces C=C casi paralelos y próximos en el espacio. ...
1. (R)-Phenylglycinol-derived oxazolopiperidone lactams can be converted to enantiopure open-chain amino ester scaffolds by alkaline hydrolysis of the N-Boc 2-piperidones resulting from the reductive cleavage of the ...
Among transition metals used in organic chemistry, palladium has greatly contributed to the development of modern organic synthesis. This thesis is focused on the development of novel and efficient methodologies for the ...
Transition metal-catalyzed intramolecular C–H insertions of diazo compounds represent one of the most elegant and versatile methods in organic synthesis for the construction of carbocyclic and heterocyclic frameworks. ...
Existe una correlación positiva entre el incremento de la esperanza de vida y el aumento de las enfermedades crónicas. Se ha establecido que el envejecimiento es el principal factor de riesgo en la aparición de trastornos ...
The sigma-1 receptor is a chaperone that is primarily expressed in the mitochondria-associated endoplasmic reticulum (MAM). It was cloned years ago from different tissues of various species and its structure ...
[cat] Aquest treball està orientat en l’estudi de nous sistemes heterocíclics nitrogenats amb potencial activitat biològica, concretament, en la recerca de nous antitumorals per inhibició enzimàtica. S’ha descrit la ...
[eng] Intrauterine growth restriction (IUGR) is defined as a significant reduction on fetal growth rate, resulting in a birth weight below the 10th percentile for the corresponding gestational age (Sharma et al., 2016). ...
Los alcaloides decahidroquinolínicos (DHQs) representan un pequeño grupo de productos naturales aislados mayoritariamente de fuentes animales, ya sean de origen terrestre o de origen marino, y en menor medida de fuentes ...
La síntesis de compuestos orgánicos heterocíclicos permite acceder a un amplio arsenal de compuestos con potencial actividad farmacológica. El presente manuscrito se enmarca en el campo de la química farmacéutica, desarrollando ...
La calispongiolida es un macrólido aislado en el año 2013 a partir de un extracto metanólico de la esponja Callyspongia sp. recogida en la costa de Indonesia. Este producto natural posee una potente actividad citotóxica y ...
The world is facing an unprecedented situation: soon the number of people over 60 years old will exceed the number of children, and more people at extreme old age than ever before. This is due to medical advances that have ...
Sphingolipids (SLs) are components of eukaryotic cell membranes that in the last 30 years have shown not only a structural role but also be involved in signaling processes and cellular responses. Therefore, the development ...
The synthesis of heterocyclic organic compounds allows access to a wide arsenal of compounds with potential pharmacological activity. This Thesis is part of the field of pharmaceutical chemistry, developing new therapeutic ...
The identification of imidazoline receptors (IR) as a novel class of receptors has posed manifold research questions regarding their pharmacological and potential therapeutic properties. Among them, I2-IR receptors are ...
This doctoral thesis consists in two main parts. The first part focus in the study of methodology development in order to bring modularity and diversification to compounds studied within the research group. It consists ...
