Synthesis of 2-Vinyl sphingolipids as S1PL inhibitors 

    Calderón i Almendro, Raquel (Fecha de defensa: 2017-03-14)

    Sphingolipids (SLs) are components of eukaryotic cell membranes that in the last 30 years have shown not only a structural role but also be involved in signaling processes and cellular responses. Therefore, the development ...

    Synthesis of nitrogenated compounds with potential interest for the treatment of Unmet Medical Needs 

    Bagán Polonio, Andrea (Fecha de defensa: 2022-09-23)

    The synthesis of heterocyclic organic compounds allows access to a wide arsenal of compounds with potential pharmacological activity. This Thesis is part of the field of pharmaceutical chemistry, developing new therapeutic ...

    Targeting the I(2) Imidazoline Receptors: the neuroprotective role of selective ligands in Alzheimer’s Disease 

    Vasilopoulou, Foteini (Fecha de defensa: 2021-09-21)

    The identification of imidazoline receptors (IR) as a novel class of receptors has posed manifold research questions regarding their pharmacological and potential therapeutic properties. Among them, I2-IR receptors are ...

    Total Synthesis of Phlegmarine Alkaloids 

    Bosch, Caroline (Fecha de defensa: 2016-10-21)

    This doctoral thesis consists in two main parts. The first part focus in the study of methodology development in order to bring modularity and diversification to compounds studied within the research group. It consists ...

    Toward the Synthesis of Daphniphyllum Alkaloids using Radical Chemistry 

    Coussanes, Gilhem (Fecha de defensa: 2016-12-16)

    The manuscript of this Doctoral Thesis has been divided into five main parts: a general introduction into the calyciphylline A-type alkaloids followed by three research chapters and conclude by a review about the radical ...

    Una estrategia unificada para la síntesis enantioselectiva de los alcaloides del grupo de las madangaminas 

    Are, Celeste (Fecha de defensa: 2018-09-28)

    El presente trabajo se centra en los alcaloides del grupo de las madangaminas, un pequeño grupo de alcaloides diaminopentacíclicos, aislados de esponjas marinas pertenecientes al orden Haplosclerida y derivados biogenéticamente ...

    Validación de dianas farmacológicas para la prevención y el tratamiento de la hipertrigliceridemia y el hígado graso inducidos por el consumo de fructosa líquida y dieta rica en grasa saturada 

    Velázquez Chávez, Ana Magdalena (Fecha de defensa: 2021-11-09)

    La enfermedad del hígado graso no alcohólico es una patología sin tratamiento farmacológico específico que posee una alta prevalencia a nivel mundial, cuya etapa inicial se caracteriza por la esteatosis hepática simple. ...