Chiral tricyclic lactams as efficient enantiomeric scaffolds for the synthesis of cis-decahydroquinolines substituted on the carbocyclic ring. Total synthesis of Myrioneuron alkaloids 

    Calbó Zabala, Arnau (Date of defense: 2024-02-16)

    [eng] The Myrioneuron alkaloids constitute a family of natural products found in East and South-East Asia. They feature a cis- or trans-decahydroquinoline (DHQ) as a common unit, attached to an oxazine, a diazine, or a ...

    Design and synthesis of sphingosine-1-phosphate lyase inhibitors and fluorogenic probes for the development of HTS assays 

    Sanllehí Figuerola, Pol (Date of defense: 2016-11-02)

    Sphingolipids (SLs) are essential structural and signaling molecules of eukaryotic cells. An important group of SLs metabolites are those showing a phosphate group at the C1‒ OH. Among them, sphingosine‒1‒phosphate (S1P) ...

    Generació de "building blocks" enantiopurs amb un estereocentre quaternari. Aplicació a la síntesi de productes naturals i compostos biològicament actius 

    Ordeix i Utiel, Sergi (Date of defense: 2022-11-11)

    [cat] Els alcaloides indòlics monoterpènics del grup leuconolam-leuconoxina-mersicarpina [(–)- mersicarpina, (–)-leuconoxina, (+)-melodinina E] i la (–)-kopsiyunnanina K presenten una interessant activitat biològica juntament ...

    Isocyanide as a key functional group for the synthesis of biologically active compounds 

    Abás Prades, Sònia (Date of defense: 2018-05-31)

    The distinctive reactivity of isocyanides has been recognised as an advantageous characteristic for the formation of heterocyclic compounds. In the present manuscript new synthetic possibilities are explored involving the ...

    New Palladium-Catalysed Intramolecular Coupling Reactions: Nucleophilic Addition toAldehydes and C-H Carbene Insertion 

    Mariani, Francesco (Date of defense: 2016-07-05)

    Although sygma-aryl and sygma-vinylpalladium(II) complexes are commonly used as electrophiles in C—C bond forming reactions, recent research has demonstrated that the same palladium intermediates can also react with ...

    Nuevas aproximaciones a compuestos policíclicos complejos y transformaciones de los mismos 

    Otermin Esteras, Ane (Date of defense: 2016-11-23)

    En esta Tesis doctoral, se ha puesto a punto una ruta sintética para acceder de manera rápida y eficaz, a compuestos policíclicos tipo “cinturón” que contienen dos dobles enlaces C=C casi paralelos y próximos en el espacio. ...

    Palladium in azaheterocyclic synthesis: α-arylation of sulfones, domino processes and C-H carbene insertion reactions 

    Pérez Janer, Ferran (Date of defense: 2018-06-01)

    Among transition metals used in organic chemistry, palladium has greatly contributed to the development of modern organic synthesis. This thesis is focused on the development of novel and efficient methodologies for the ...

    Palladium, ruthenium and iron in intramolecular transition metal-catalyzed carbene functionalization reactions of amino-tethered α-diazoesters 

    Amenta, Arianna (Date of defense: 2020-03-27)

    Transition metal-catalyzed intramolecular C–H insertions of diazo compounds represent one of the most elegant and versatile methods in organic synthesis for the construction of carbocyclic and heterocyclic frameworks. ...

    Síntesis de alcaloides decahidroquinolínicos de los grupos de la gefirotoxina, flegmarina y cilindricina 

    Piccichè, Miriam (Date of defense: 2021-12-10)

    Los alcaloides decahidroquinolínicos (DHQs) representan un pequeño grupo de productos naturales aislados mayoritariamente de fuentes animales, ya sean de origen terrestre o de origen marino, y en menor medida de fuentes ...

    Síntesis de compuestos bioactivos: Ligandos de los receptores imidazolínicos I(2) e inhibidores de la enzima PEPCK 

    Rodríguez Arévalo, Sergio (Date of defense: 2021-11-26)

    La síntesis de compuestos orgánicos heterocíclicos permite acceder a un amplio arsenal de compuestos con potencial actividad farmacológica. El presente manuscrito se enmarca en el campo de la química farmacéutica, desarrollando ...

    Synthesis of 2-Vinyl sphingolipids as S1PL inhibitors 

    Calderón i Almendro, Raquel (Date of defense: 2017-03-14)

    Sphingolipids (SLs) are components of eukaryotic cell membranes that in the last 30 years have shown not only a structural role but also be involved in signaling processes and cellular responses. Therefore, the development ...

    Una estrategia unificada para la síntesis enantioselectiva de los alcaloides del grupo de las madangaminas 

    Are, Celeste (Date of defense: 2018-09-28)

    El presente trabajo se centra en los alcaloides del grupo de las madangaminas, un pequeño grupo de alcaloides diaminopentacíclicos, aislados de esponjas marinas pertenecientes al orden Haplosclerida y derivados biogenéticamente ...