Browsing Departament de Farmacologia, Toxicologia i Química Terapèutica by Subject "577"

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G9a, a histone lysine methylatransferase, as a potential target for Alzheimer’s disease

Bellver Sanchis, Aina (Date of defense: 2024-04-22)

[eng] Alzheimer’s disease (AD) is the most common cause of dementia that currently lacks effective pharmacological treatment. Identifying new targets to halt disease progression is a pressing need. In most cases, AD has a ...

GDF15, a novel regulator of the AMPK-mediated antidiabetic actions of PPARβ/δ and metformin

Aguilar Recarte, David (Date of defense: 2021-09-20)

Type 2 diabetes (T2D) is a multifactorial disease that comprises metabolic defects in multiple organs. Several studies have shown that the presence of a chronic low-state inflammatory process induces the development of ...

Neurochemical and psychopharmacological study of MDPV, a cocaine-like psychostimulant. Characterization of structurally-related second-generation synthetic cathinones

Duart Castells, Leticia (Date of defense: 2020-02-25)

Drugs of abuse represent a global problem not only at a health level, but also at a social and economic extent. Recently, a tidal wave of new emerging psychoactive substances has completely modified the illicit drug market, ...

Phenotyping of sigma-1 receptor knock-out rodents

Codony Soler, Xavier (Date of defense: 2022-06-02)

The sigma-1 receptor is a chaperone that is primarily expressed in the mitochondria-associated endoplasmic reticulum (MAM). It was cloned years ago from different tissues of various species and its structure ...

Study of the effects of PPAR-β/δ activators in the treatment of MASH

Zhang, Meijian (Date of defense: 2024-07-19)

[eng] Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), is the most common chronic liver disease around the world, affecting more than 30% of the ...