Browsing Departament de Farmacologia, Toxicologia i Química Terapèutica by Title

Characterization of epigenetic and transcriptional changes in aging and Alzheimer’s disease

Cosín Tomàs, Marta (Date of defense: 2017-02-28)

Epigenetic changes are currently recognized as part of the aging process and have been implicated in many age-related chronic diseases such as Alzheimer’s disease (AD). The term epigenetics includes a variety of processes ...

Chiral tricyclic lactams as efficient enantiomeric scaffolds for the synthesis of cis-decahydroquinolines substituted on the carbocyclic ring. Total synthesis of Myrioneuron alkaloids

Calbó Zabala, Arnau (Date of defense: 2024-02-16)

[eng] The Myrioneuron alkaloids constitute a family of natural products found in East and South-East Asia. They feature a cis- or trans-decahydroquinoline (DHQ) as a common unit, attached to an oxazine, a diazine, or a ...

Chloroacetamides as Valuable Synthetic Tools to Access Nitrogen-Containing Heterocycles Using Both Radical and Non-Radical Processes

Montiel Achong, Juan Andrés (Date of defense: 2016-12-20)

Durante este trabajo de tesis doctoral se ha demostrado que las cloroacetamidas son intermedios de gran utilidad para la síntesis de heterociclos nitrogenados a través de procesos radicalarios o no radicalarios. En este ...

Common scaffolds for the enantioselective synthesis of marine, plant, and amphibian cis-decahydroquinoline alkaloids

Pinto, Alexandre (Date of defense: 2017-09-28)

Chiral amino alcohol derived lactams are a valuable scaffold for the enantioselective synthesis of alkaloids. In the present thesis the potential of this methodology was expanded and to demonstrate the synthetic utility ...

Design and synthesis of heterocyclic compounds potentially antitumor by enzymatic inhibition

Lizano Gispert, Enric (Date of defense: 2020-07-24)

This doctoral thesis is focused on the investigation and development of new compounds directed to different cancer and tropical diseases targets. Drug resistance, as well in cancer as in tropical diseases, is a hurdle which ...

Design and synthesis of sphingosine-1-phosphate lyase inhibitors and fluorogenic probes for the development of HTS assays

Sanllehí Figuerola, Pol (Date of defense: 2016-11-02)

Sphingolipids (SLs) are essential structural and signaling molecules of eukaryotic cells. An important group of SLs metabolites are those showing a phosphate group at the C1‒ OH. Among them, sphingosine‒1‒phosphate (S1P) ...

Development of a divergent strategy towards the synthesis of lycopodium alkaloids

Saborit Villarroya, Gisela (Date of defense: 2016-07-19)

En la present tesi doctoral s’ha desenvolupat una estratègia per obtenir els esquelets dels quatre alcaloides licopodi representatius a partir d’un mateix intermedi sintètic comú 1, de manera semblant al procés que té lloc ...

Development of New Multicomponent Processes based on Unexplored Chemistry of Isocyanides: Access to Heterocyclic Scaffolds and Applications

Ghashghaei, Ouldouz (Date of defense: 2017-09-26)

1. It was observed that the interaction of imines and isocyanides in the presence of a Lewis acid can lead to a variety of scaffolds including α-aminoamides, α-aminoamidines, indoles and diiminoazetidines. The reaction ...

Developmental toxicity screening in the zebrafish embryo – a metabolomics approach

Wilhelmi, Pia Rosa Maria (Date of defense: 2024-07-19)

[eng] Birth defects occur in about 3-6% of human births worldwide (CDC, 2023). To mitigate the risk to the unborn child, the assessment of embryo-fetal developmental toxicity is an integral part of chemical registration ...

El déficit cognitivo y la enfermedad de Alzheimer en presencia de alteraciones metabólicas: Estudio in vivo de una nueva diana terapéutica y de la estrategia multidiana para el tratamiento de estas condiciones

Espinosa Jiménez, Triana (Date of defense: 2023-09-26)

[spa] La enfermedad de Alzheimer (EA) es el tipo de demencia más común. En los últimos años su prevalencia se ha incrementado preocupantemente, considerándose la epidemia del siglo XXI. Hasta ahora solo se han conseguido ...

Efectes metabòlics, vasculars i cognitius del consum de sucres simples en rates femella

Sangüesa Puigventós, Gemma (Date of defense: 2017-04-18)

En les últimes dècades, l’increment del consum de sucres, especialment de fructosa, s’ha associat al desenvolupament de la obesitat i d’alteracions metabòliques com ara diabetis, hipertensió i malalties cardiovasculars. ...

Efecto del síndrome metabólico provocado por una dieta rica en grasa en ratones APPswe/PS1dE9, modelo experimental de la enfermedad de Alzheimer, y posibles terapias farmacológicas

Ettcheto Arriola, Miren (Date of defense: 2018-03-16)

La enfermedad de Alzheimer (EA) es el tipo de demencia progresiva más común. En base al incremento de la prevalencia esperada, es considera la epidemia del siglo XXI. En consecuencia, surge una gran necesidad de encontrar ...

Enantio- and Diastereoselective Cyclocondensation Reactions. Stereocontrolled Access to Azabicycles and Application to Natural Product Synthesis

Ghirardi, Elena (Date of defense: 2016-07-28)

The first objective of this Thesis was the study of the preparation of octhydro-1H-cyclopenta[b]pyridines and octahydro-1H-indoles, through the synthesis of (R)-phenylglycinol derived tricyclic lactams. Following the ...

From the design to the in vivo evaluation of novel soluble epoxide hydrolase inhibitors

Codony Gisbert, Sandra (Date of defense: 2020-09-17)

Epoxieicosatrienoic acids acids (EETs) are endogenous chemical mediators derived from arachidonic acid that show anti-inflammatory, antihypertensive, analgesic, angiogenic and antiatherosclerotic effects. Soluble epoxide ...

G9a, a histone lysine methylatransferase, as a potential target for Alzheimer’s disease

Bellver Sanchis, Aina (Date of defense: 2024-04-22)

[eng] Alzheimer’s disease (AD) is the most common cause of dementia that currently lacks effective pharmacological treatment. Identifying new targets to halt disease progression is a pressing need. In most cases, AD has a ...

GDF15, a novel regulator of the AMPK-mediated antidiabetic actions of PPARβ/δ and metformin

Aguilar Recarte, David (Date of defense: 2021-09-20)

Type 2 diabetes (T2D) is a multifactorial disease that comprises metabolic defects in multiple organs. Several studies have shown that the presence of a chronic low-state inflammatory process induces the development of ...

Generació de "building blocks" enantiopurs amb un estereocentre quaternari. Aplicació a la síntesi de productes naturals i compostos biològicament actius

Ordeix i Utiel, Sergi (Date of defense: 2022-11-11)

[cat] Els alcaloides indòlics monoterpènics del grup leuconolam-leuconoxina-mersicarpina [(–)- mersicarpina, (–)-leuconoxina, (+)-melodinina E] i la (–)-kopsiyunnanina K presenten una interessant activitat biològica juntament ...

Isocyanide as a key functional group for the synthesis of biologically active compounds

Abás Prades, Sònia (Date of defense: 2018-05-31)

The distinctive reactivity of isocyanides has been recognised as an advantageous characteristic for the formation of heterocyclic compounds. In the present manuscript new synthetic possibilities are explored involving the ...

Mecanismos implicados en la neurodegeneración inducida por dieta grasa en modelos de senescencia

Palomera Ávalos, Verónica (Date of defense: 2018-01-26)

La población mundial está envejeciendo, la mayoría de países del mundo están experimentando un aumento en el número y la proporción de personas mayores. Los últimos datos publicados de la ONU en 2017 informan que se espera ...

Modificaciones en la herencia epigenética inducidas por la dieta grasa revertidas por el resveratrol en el modelo murino SAMP8

Izquierdo Cadenas, Vanesa (Date of defense: 2021-07-21)

Factores ambientales como el ejercicio, el estrés o la dieta contribuyen a la patogénesis de enfermedades asociadas al deterioro cognitivo y al envejecimiento, modulando mecanismos de expresión génica que son susceptibles ...