Ara mostrant els elements 1-8 de 8
Martínez Cartró, Míriam (Data de defensa: 2021-10-25)
Advances in structural and molecular biology have increased the knowledge of relevant and undrugged targets and have favoured the rational development of novel drugs through structure- based ...
Abreu, Marcelle Silva de (Data de defensa: 2018-07-24)
La pioglitazona (PGZ) es un agonista del peroxisoma proliferador activado del receptor gamma (PPARγ) receptor, pertenece a la clase de las tiazolidindionas y es usado para el tratamiento de la diabetes ...
Rachman, Moira (Data de defensa: 2020-09-23)
Fragment-based drug design is an established strategy of finding new drugs. Instead of doing mass screening of chemical libraries containing compounds that are already lead-like, starting from a small ...
Ruiz Carmona, Sergio (Data de defensa: 2017-01-20)
The main motivation of this thesis has been to validate, improve and develop new methods with respect to the ones available nowadays in the area of drug discovery, in order to be able to study more ...
Ruiz García, Marta (Data de defensa: 2020-10-20)
In today’s society, people’s interest against health care is growing every day. On a health- concerned population, food supplements and nutraceuticals are products with an increasing interest among the ...
Piticchio, Serena (Data de defensa: 2021-05-11)
Efficient discovery of bioactive molecules is an essential goal of Computer-Aided Drug Design (CADD). The molecules can be used as chemical probes, to validate novel targets, or as starting points for ...
Majewski, Maciej (Data de defensa: 2020-07-17)
The relevance of structural stability in drug design has been shown by the use of DUck in virtual screening campaign, as reported previously. The method provides a fast and easy way to assess hydrogen ...
Botet Carreras, Adrià (Data de defensa: 2022-03-21)
The research in this thesis aimed to study and generate an engineered formulation that can fuse with cell membranes and carry drugs or other compounds into cells. HeLa cells were chosen as the target ...