Departament de Biologia Cel·lular, Fisiologia i Immunologia

Recent Submissions

Regulación del metabolismo neuronal. Papel de la actividad sináptica e implicación en la fisiopatología del síndrome de Leigh 

Tena Morraja, Paula (Date of defense: 2024-07-19)

[spa] La mayor parte del gasto energético en el cerebro se utiliza en procesos relacionados con la transmisión sináptica. La actividad sináptica provoca adaptaciones estructurales y funcionales en las que se potencian las ...

Nutrition and gut microbiota modulation as tools for regulating fat accumulation in aquaculture fish 

Ruiz Hernández, Alberto (Date of defense: 2024-07-12)

[eng] The sustainability concerns, increasing cost, and insufficient availability of fish oil associated to aquaculture growth, have led to the search of sustainable alternatives in aquafeeds. However, fish oil replacement ...

Respuestas cardiorrespiratorias, metabólicas, mecánicas y de estrés oxidativo, agudas y crónicas, en la danza aeróbica realizada sobre una plataforma de disipación de aire en personas adultas jóvenes y mayores 

Moreira Reis, Alessandra (Date of defense: 2023-12-15)

[spa] INTRODUCCIÓN: La danza aeróbica (AD) es una modalidad de ejercicio de las más practicadas en el mundo que ha demostrado múltiples beneficios en la salud de aquellas personas que la practican, especialmente en la ...

Development of 3D in vitro platforms for the study of muscle function and axonal growth and regeneration 

Wells Cembrano, Karen Isabel (Date of defense: 2023-10-27)

[eng] The use of in vitro models in biomedical research offers an invaluable tool for exploring biological processes of health and disease. While animal models remain highly informative and necessary to ensure clinical ...

The role of CLA+T lymphocytes in the development of Atopic Dermatitis 

Sans de San Nicolàs, Lídia (Date of defense: 2023-10-26)

[eng] Atopic dermatitis is the most common chronic immune-mediated inflammatory skin disease affecting up to 20% of children and 10% of adults. The complex pathophysiology of the disease comprises genetic susceptibility, ...

Anàlisi de les funcions de la proteïna NCAM2 en desenvolupament i plasticitat neuronal 

Ortega Gascó, Alba (Date of defense: 2023-07-07)

[eng] The Central Nervous System (NS) is a fascinating and complex structure formed by millions of interconnected neurons that facilitate cognitive tasks such as memory and learning. The development and maintenance of this ...

Evaluation of tau seeding, spreading, and cytotoxicity using in vitro and in vivo models of tau pathology 

Sala Jarque, Júlia (Date of defense: 2023-02-01)

[eng] Abnormal folding, hyperphosphorylation, aggregation, and subsequent deposition of the microtubule-associated protein tau, is the hallmark of a group of devastating neurodegenerative diseases known as tauopathies, ...

Implicación del Sistema de Melanocortinas en la Reproducción del Pez Cebra 

Navarro Rojas, Sandra Ximena (Date of defense: 2023-01-20)

[spa] El sistema de melanocortinas es probablemente uno de los sistemas hormonales más complejos involucrados en la regulación de la ingesta de alimentos y la homeostasis energética. Las melanocortinas son péptidos derivados ...

Secretory and synaptic proteins in brain and cerebrospinal fluid in normal and Alzheimer’s disease animal models 

Sánchez Domínguez, Irene (Date of defense: 2022-11-25)

[eng] The central nervous system represents a huge network architecture where intercellular communication governs and coordinates the proper function of the brain. Regulated secretion of neuropeptides and growth factors ...

Effects of the pharmacological activation of Liver X Receptors in the tumor microenvironment 

Font Díaz, Joan (Date of defense: 2022-07-22)

Nuclear receptors are a superfamily of ligand-dependent transcription factors that are involved in numerous biological processes in homeostasis and disease. Liver X receptors (LXRs) are members of the nuclear receptors ...

Characterization of a new animal model of Alzheimer's disease: relevance of Tau phosphorylation in hippocampal interneurons 

Dávila Bouziguet, Eva (Date of defense: 2022-06-03)

The neuropathological hallmarks of Alzheimer’s disease are senile plaques, extracellular deposits of amyloid-β peptide (Aβ), and neurofibrillary tangles, intracellular aggregates of hyperphosphorylated Tau protein (P-Tau). ...

Fisiología digestiva y nutrición durante las primeras etapas de vida del pez gato amazónico Pseudoplaystoma punctifer (Castelnau, 1899) en cultivo 

Castro Ruíz, Diana (Date of defense: 2022-05-16)

El pescado es una de las principales fuentes de proteínas para la población de la cuenca amazónica, la cual posee la mayor biodiversidad de peces del mundo. La acuicultura se ha desarrollado de manera constante en la región ...

Activity-dependent mechanisms of axonal growth 

Mesquida Veny, Francina (Date of defense: 2022-04-01)

Spinal cord injuries (SCI) are a major cause of paralysis in young adults. In this type of injuries recovery is impaired as adult central nervous system (CNS) axons fail to regenerate. This results from both a loss of ...

New insights about the role of WT1 in blood vessel formation during development and repair 

Ramiro-Pareta, Marina (Date of defense: 2022-03-31)

The pleiotropic WT1 transcription factor (WT1) was first discovered in renal tumours. It contains four zinc-finger motifs at the C-terminus which are important for DNA binding to activate gene expression and is also involved ...

Gestational exercise and intergenerational inheritance. Metabolic and functional outcomes in rat liver and skeletal muscle 

Beleza, Jorge (Date of defense: 2022-04-05)

Maternal environmental exposure during gestational period may affect offspring risk for chronic diseases. Accordingly, maternal metabolic disturbances induced by high-fat high-sucrose (HFHS) diets can have a negative impact ...

Análisis de los efectos globales que ocasiona la hipoxia hipobárica crónica sobre el estado físico-emocional de los pobladores que residen en altitudes mayores a los 2,500 msnm 

Ortiz Prado, Esteban (Date of defense: 2022-03-11)

ANTECEDENTES: A nivel planetario, al menos 200 millones de personas a nivel mundial residen en poblaciones ubicadas a grandes alturas. Vivir o visitar regiones montañosas puede provocar cambios fisiológicos significativos ...

Factores físicos y moleculares implicados en la migración celular y en el desarrollo de la corteza cerebral 

López Mengual, Ana (Date of defense: 2022-01-12)

La migración celular adquiere especial relevancia durante el desarrollo embrionario y la regeneración tisular. Durante el desarrollo del individuo adulto, las células se multiplican, se diferencian y maduran, debiéndose ...

Efecto de la hipoxia hipobárica intermitente y el frío en la recuperación de lesiones del músculo esquelético 

Santocildes Martinez, Garoa (Date of defense: 2021-12-17)

Los trastornos músculo-esqueléticos son una de las principales causas de necesidad de rehabilitación en el mundo. En el ámbito deportivo, las lesiones del sistema musculo- esquelético representan entre el 10-55% del total ...

Mechanisms of LXR-mediated control of obesity-induced metaflammation and insulin-resistance 

Letelier Torres, Nicole Alejandra (Date of defense: 2021-12-14)

Obesity is nowadays considered a pandemic disease, and its incidence correlates with the concomitant increase of a set of associated comorbidities, including T2D, cardiovascular diseases, fatty liver disease, among others, ...

Regulatory mechanisms of muscle growth and metabolism in fish: modulatory by nutritional status, diet composition, exercise and muscular regeneration 

Perelló Amorós, Miquel (Date of defense: 2021-10-20)

With the most absolute purpose of understanding what the “simple” concept of “growth regulation” implies, the present thesis is a compilation of original works that aims to deepen in how the growth and metabolism of fish, ...