Departament de Bioquímica i Biomedicina Molecular

La Universitat de Barcelona és la universitat pública principal de Catalunya, amb el nombre més gran d’estudiants i l’oferta formativa més àmplia i completa. A més, és el principal centre de recerca universitari de l’Estat i un dels més importants d’Europa, tant per nombre de programes de recerca com per l’excel·lència assolida en aquest terreny.Estretament vinculada a la història de Barcelona i de Catalunya, la UB combina els valors de la tradició amb el fet de ser una institució innovadora i d’excel·lència en l’àmbit docent, i és una universitat urbana, oberta i cosmopolita com la mateixa ciutat de Barcelona.Us convidem a conèixer la Universitat de Barcelona!


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Recent Submissions

TP53INP2 at the crossroad of transcription, autophagy and liver metabolism 

Sun Wang, Jia Liang (Date of defense: 2024-06-03)

[eng] Metabolic-associated steatotic liver disease (MASLD) is the leading global liver chronic disease and it is estimated to affect 30% of the world population. MASLD is a progressive multi-stage disease characterized by ...

Targeting metabolic reprogramming in metastatic colorectal and prostate cancer cells to prevent therapeutic failure 

Hernández Carro, Claudia (Date of defense: 2024-03-19)

[eng] Prostate and colorectal cancer are among the cancer types with the highest recurrence and mortality rates. The emergence of drug resistance poses a considerable challenge for effective treatment, especially in the ...

Analysis of consensus motions in proteins through molecular dynamics simulations 

Jordà Bordoy, Luis (Date of defense: 2024-02-06)

[eng] The understanding of proteins as dynamical entities rather than static structures marked a very significant advance in the interpretation of their functional role in life. The capacity of proteins to interact with ...

Estudio de la interacción de hCNT3 y QDPR como nexo funcional entre la recuperación de nucleósidos y sus vías biosintéticas 

Prieto Carruyo, Andrea Valentina (Date of defense: 2023-12-15)

[spa] Aún queda mucho por conocer sobre la regulación de la función de los transportadores concentrativos de nucleósidos hCNTs. A pesar de que se expresan en muchos tipos de tejidos, su localización no es ubicua y varía ...

Regulatory subunits controlling the Kv1.3 channelosome 

Cassinelli, Silvia (Date of defense: 2023-12-15)

[eng] The Kv1.3 voltage-dependent potassium channel plays a crucial role in the immune response participating in various cellular functions like proliferation, activation, and apoptosis. The aberrant expression of this ...

Network-based methods for biological data integration in precision medicine 

Núñez Carpintero, Iker (Date of defense: 2023-11-14)

[eng] The vast and continuously increasing volume of available biomedical data produced during the last decades opens new opportunities for large-scale modeling of disease biology, facilitating a more comprehensive and ...

Expresión y Funcionalidad de Receptores de Cannabinoides y de Adenosina y de sus Heterómeros en modelos de Alzheimer y de Esclerosis Múltiple 

Pérez Olives, Catalina (Date of defense: 2023-11-17)

[eng] Adenosine and endocannabinoids are regulatory molecules that are present in all organ and physiological systems. They act via specific receptors belonging to the G protein-coupled receptor (GPCR) superfamily. There ...

Involvement of Alternative Splicing Regulation in Adipose Tissue Thermogenic Induction 

Castellá Giner, Moisés (Date of defense: 2023-09-29)

[emg] Alternative splicing (AS) is a gene expression regulatory mechanism that enables generation of multiple mRNA isoforms from a single gene which commonly are translated into proteins. This mechanism is tightly regulated ...

Development and application of methodologies and infrastructures for cancer genome analysis within Personalized Medicine 

Royo Garrido, Romina (Date of defense: 2023-03-31)

[eng] Next-generation sequencing (NGS) has revolutionized biomedical sciences, especially in the area of cancer. It has nourished genomic research with extensive collections of sequenced genomes that are investigated to ...

Noves evidències de l’efecte neuroprotector del Sistema Cannabinoide a nivell del Sistema Nerviós Central 

Lillo Jové, Jaume (Date of defense: 2023-03-17)

[cat] El Sistema Cannabinoide, que inclou els dos receptors de cannabinoides CB1 i CB2, els seus lligands endògens i els enzims de síntesi i degradació d’aquests, és un sistema molt complex que controla un gran nombre de ...

Protein kinase-dependent Kv1.3 biology 

Estadella Pérez, Irene (Date of defense: 2023-01-20)

[eng] The voltage gated potassium channel Kv1.3 is a transmembrane protein that selectively drives potassium ions participating in the electrochemical gradient of cell membranes. This channel presents a wide distribution ...

Regulation of hepatic metabolism by the autophagic protein TP53INP2 

Frager, Petra (Date of defense: 2022-10-28)

[eng] Decreased physical activity and increased consumption of energy-rich food are hallmark lifestyle modifications that developed and amplified over the course of only a few decades. These changes in our daily behavior ...

Obesitat severa i ateroesclerosi subclínica: biologia molecular, marcadors i efecte de la cirurgia bariàtrica 

Carmona Maurici, Júlia (Date of defense: 2022-10-14)

[cat] La predicció del risc de patir un esdeveniment cardiovascular en les persones amb obesitat severa és imprecisa. A més, els mecanismes que interrelacionen l’obesitat amb l’ateroesclerosi no es coneixen amb suficient ...

Parmbsc2: Development of an accurate force field for nucleic acids simulations 

Gallego Pérez, Diego (Date of defense: 2022-09-29)

Molecular dynamics (MD) simulations are the equivalent to a computational microscope allowing us to interrogate molecules and their behaviour in complex systems. They are recognised as a valuable and accurate tool in ...

Obtención de aptámeros específicos para enzimas de la vía del metileritritol fosfato de microorganismos 

Roca Martínez, Carlota (Date of defense: 2022-07-04)

FUNDAMENTO: Microorganismos patógenos como las bacterias Mycobacterium tuberculosis y Pseudomonas aeruginosa, y los protozoos del filo Apicomplexa, incluyendo los agentes causantes de la malaria y la toxoplasmosis, sintetizan ...

Characterization of the role of TKTL1 in Acute Monocytic Leukaemia 

Baptista, Inês do Carmo Viegas (Date of defense: 2022-04-07)

Leukaemia is one of the types of cancer where treatment resistance is prevalent. Better understanding of leukemic cells metabolism opens possibilities for new therapeutic strategies and better prognosis stratification. ...

Molecular determinants of the Kv1.3/KCNE4 interaction 

Sastre Martinez, Daniel (Date of defense: 2022-04-08)

Kv1.3 plays a crucial role in leukocytes, where it regulates activation and proliferation. In these cells, Kv1.3 is coexpressed with modulatory subunit KCNE4. This ancillary peptide acts as a dominant negative regulator ...

Mitochondrial dynamics as a hub in the control of muscle inflammation 

Irazoqui Guimon, Andrea (Date of defense: 2021-12-03)

Some forms of mitochondrial dysfunction induce sterile inflammation through mitochondrial DNA (mtDNA) recognition by intracellular DNA sensors. However, our understanding of the processes operating this activation is ...

Paper dels factors neuronals SEMA3F i NTN1 en la transició de càncer de mama in situ a invasiu 

Moragas Garcia, Núria (Date of defense: 2021-02-26)

La teoria més plausible de l’evolució del càncer de mama és la que considera el carcinoma ductal in situ (DCIS) com a precursor no obligat del carcinoma ductal invasiu (IDC), que eventualment progressa cap a l’etapa ...

Papel de las cardiocinas FGF21 y Metrnl en la hipertrofia cardíaca 

Rupérez Gonzalo, Celia (Date of defense: 2020-09-10)

El objetivo principal de esta tesis fue el estudio de la función de dos nuevas cardiocinas, FGF21 y Metrnl, durante el desarrollo de la patología cardíaca. Se dividió en los siguientes apartados: PARTE 1: Caracterización ...

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