Universitat de Barcelona
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[spa] El objetivo de la presente tesis se basa en establecer, mediante el uso de modelos experimentales animales y celulares, cuál es el papel de la enterocina FGF15/19: a) en la adiposidad y plasticidad de los ...
El objetivo principal de esta tesis fue el estudio de la función de dos nuevas cardiocinas, FGF21 y Metrnl, durante el desarrollo de la patología cardíaca. Se dividió en los siguientes apartados: PARTE 1: Caracterización ...
La teoria més plausible de l’evolució del càncer de mama és la que considera el carcinoma ductal in situ (DCIS) com a precursor no obligat del carcinoma ductal invasiu (IDC), que eventualment progressa cap a l’etapa ...
Molecular dynamics (MD) simulations are the equivalent to a computational microscope allowing us to interrogate molecules and their behaviour in complex systems. They are recognised as a valuable and accurate tool in ...
Los glucocorticoides (GCs), un grupo de hormonas esteroides secretadas por la glándula suprarrenal, controlan el equilibrio entre movilización y deposición de reservas energéticas en el organismo y desempeñan papeles ...
[eng] The voltage gated potassium channel Kv1.3 is a transmembrane protein that selectively drives potassium ions participating in the electrochemical gradient of cell membranes. This channel presents a wide distribution ...
Nucleosides and nucleotides have a key role in cell physiology being implicated in crucial processes such as DNA and RNA synthesis, cell signaling and metabolic regulation. Purine and pyrimidine nucleotide balance is ...
Els transportadors de nucleòsids pertanyen a les famílies gèniques SLC28 i SLC29 que codifiquen pels transportadors de nucleòsids concentratius (hCNTs) i transportadors de nucleòsids equilibratius (hENTs), respectivament. ...
Overweight and obesity have increased dramatically during recent decades becoming a major health problem for which therapeutic options are limited. Thus, there is an urgent need to develop new safe pharmacological therapies. ...
[eng] Decreased physical activity and increased consumption of energy-rich food are hallmark lifestyle modifications that developed and amplified over the course of only a few decades. These changes in our daily behavior ...
[eng] The Kv1.3 voltage-dependent potassium channel plays a crucial role in the immune response participating in various cellular functions like proliferation, activation, and apoptosis. The aberrant expression of this ...
G-protein coupled receptors (GPCR) constitute a complex and versatile superfamily of membrane receptors with relevance in maintaining homeostasis. The thesis project has focused in members of this superfamily: the CB1 and ...
Obesity prevalence has tripled in the last fifty years. For this reason, it is considered the pandemic of the century. It is characterized by the accumulation of metabolic abnormalities triggered by an increase in the size ...
Metastasis is the main cause of cancer-related deaths and it is of great biomedical importance to develop new therapeutic strategies that specifically target metastatic cells. Therefore, a better comprehension of the process ...
Voltage-gated K channels (Kv) is large family of channels that are expressed in both excitable and non-excitable cells. In excitable cells they contribute to the control of resting membrane potential and action potentials ...
Parkinson’s disease (PD) is an incurable neurodegenerative disorder, mainly characterized by a progressive loss of midbrain dopaminergic (DA) neurons, located in the substantia nigra pars compacta (SNpc), and frequently ...
