Universitat de Barcelona
Now showing items 21-40 of 66
Nucleosides and nucleotides have a key role in cell physiology being implicated in crucial processes such as DNA and RNA synthesis, cell signaling and metabolic regulation. Purine and pyrimidine nucleotide balance is ...
Los transportadores concentrativos de nucleósidos (CNT) se han descrito como transportadores dependientes de sodio y de alta afinidad para los nucleósidos naturales. Su expresión se consideró inicialmente restringida a ...
Ion channels are transmembrane proteins containing aqueous pores which, once open, permit the pass of ions through the plasma membrane. This ion flux takes places following the electrochemical gradient for the specific ...
Els transportadors de nucleòsids pertanyen a les famílies gèniques SLC28 i SLC29 que codifiquen pels transportadors de nucleòsids concentratius (hCNTs) i transportadors de nucleòsids equilibratius (hENTs), respectivament. ...
The vascular endothelium is one of the major targets of oxidative stress, playing an important role in the development of vascular-related disorders, such as atherosclerotic disease1. Oxidative stress increases the formation ...
The wide variety of disorders associated with the malfunction of amino acid (AA) transporters reflect the relevant roles they fulfil in human physiology. Heteromeric AA transporters (HATs), one of the eleven families of ...
L’obesitat s’ha convertit en les últimes dècades en un greu problema per la salut pública arribant a ser una de les principals causes de morbiditat, incapacitació i mortalitat prematura. Un teixit que pot tenir un paper ...
La lipoproteïna lipasa (LPL) és un enzim àmpliament distribuït a l’organisme i aquest fet li confereix un rol central en el metabolisme lipídic. La seva funció principal és la hidròlisi dels triacilglicèrids de les ...
Overweight and obesity have increased dramatically during recent decades becoming a major health problem for which therapeutic options are limited. Thus, there is an urgent need to develop new safe pharmacological therapies. ...
The endothelium plays a pivotal role in the development of cardiovascular disease (CVD) and emerging evidence indicates that pathological blood vessel responses and endothelial dysfunction are associated with metabolic ...
Metabolism is a hallmark of life and underlies most biological processes in both health and disease. For instance, dysregulation of liver metabolism underlies multifactorial disorders such as diabetes or obesity. Similarly, ...
Voltage gated K+ channels (Kv) are transmembrane proteins that allow the pass-thorugh of potassium ions, regulating the electrochemical gradient of the cell membrane. This way, they modulate several physiological processes, ...
La atención es el proceso cognitivo básico que nos otorga la capacidad de seleccionar aquella información interna o externa que va a ser relevante para la toma de decisiones y el control del comportamiento. Múltiples ...
OPA1 is a dynamin-related protein that is responsible for the fusion of the internal mitochondrial membrane and essential to control the morphology of the mitochondrial cristae. Thus, it directly impacts the efficiency of ...
Maintenance of balanced nucleotide pools is necessary for cellular homeostasis. The nucleotide content of the cell is determined by the uptake of nucleosides by specific transporters, the salvage pathway and de novo synthesis ...
Human Concentrative Nucleoside Transporters (hCNTs) are encoded by SLC28 gene family. It has been demonstrated that hCNT1 is lost in some cancers. Furthermore, hCNTs have the ability of translocating selected nucleoside- ...
Cardiovascular diseases are one of the leading causes of mortality in industrialized countries and are caused by genetic factors, environmental factors or comorbidities. This thesis is focused on three cardiovascular risk ...
El objetivo principal de esta tesis fue el estudio de la función de dos nuevas cardiocinas, FGF21 y Metrnl, durante el desarrollo de la patología cardíaca. Se dividió en los siguientes apartados: PARTE 1: Caracterización ...
Metastasis is the main cause of cancer-related deaths and it is of great biomedical importance to develop new therapeutic strategies that specifically target metastatic cells. Therefore, a better comprehension of the process ...
