Angelats Canals, Edgar (Date of defense: 2018-09-14)
G-protein coupled receptors (GPCR) constitute a complex and versatile superfamily of membrane receptors with relevance in maintaining homeostasis. The thesis project has focused in members of this ...
Capera Aragonés, Jesusa (Date of defense: 2019-12-20)
Kv1.3 is a voltage-gated potassium channel mainly expressed at the plasma membrane and at the inner mitochondrial membrane of different cell types. A dual role for the channel has been suggested: Plasma ...
Styrczewska, Katarzyna (Date of defense: 2017-09-22)
Voltage-gated K channels (Kv) is large family of channels that are expressed in both excitable and non-excitable cells. In excitable cells they contribute to the control of resting membrane potential ...
Irazoqui Guimon, Andrea (Date of defense: 2021-12-03)
Some forms of mitochondrial dysfunction induce sterile inflammation through mitochondrial DNA (mtDNA) recognition by intracellular DNA sensors. However, our understanding of the processes operating this ...
Tarragó Celada, Josep (Date of defense: 2020-09-16)
Metastasis is the main cause of cancer-related deaths and it is of great biomedical importance to develop new therapeutic strategies that specifically target metastatic cells. Therefore, a better ...
Casadó Anguera, Verònica (Date of defense: 2018-06-14)
Catecholamines, including dopamine (DA) and norepinephrine (NE), are widely distributed in the body and constitute a class of conventional neurotransmitters and hormones that occupy key positions in the ...
Serrano Albarrás, Antonio (Date of defense: 2018-11-23)
Ion channels are transmembrane proteins containing aqueous pores which, once open, permit the pass of ions through the plasma membrane. This ion flux takes places following the electrochemical gradient ...
Barros, Susana Raquel Costa (Date of defense: 2020-02-13)
OPA1 is a dynamin-related protein that is responsible for the fusion of the internal mitochondrial membrane and essential to control the morphology of the mitochondrial cristae. Thus, it directly impacts ...
Sabaté Pérez, Alba (Date of defense: 2019-10-21)
Overweight and obesity have increased dramatically during recent decades becoming a major health problem for which therapeutic options are limited. Thus, there is an urgent need to develop new safe ...
Sastre Martinez, Daniel (Date of defense: 2022-04-08)
Kv1.3 plays a crucial role in leukocytes, where it regulates activation and proliferation. In these cells, Kv1.3 is coexpressed with modulatory subunit KCNE4. This ancillary peptide acts as a dominant ...