Departament de Bioquímica i Biomedicina Molecular: Recent submissions
Now showing items 21-40 of 70
Paper dels factors neuronals SEMA3F i NTN1 en la transició de càncer de mama in situ a invasiu
La teoria més plausible de l’evolució del càncer de mama és la que considera el carcinoma ductal in situ (DCIS) com a precursor no obligat del carcinoma ductal invasiu (IDC), que eventualment progressa cap a l’etapa ...
Papel de las cardiocinas FGF21 y Metrnl en la hipertrofia cardíaca
El objetivo principal de esta tesis fue el estudio de la función de dos nuevas cardiocinas, FGF21 y Metrnl, durante el desarrollo de la patología cardíaca. Se dividió en los siguientes apartados: PARTE 1: Caracterización ...
Expresión y funcionalidad de los heterómeros de GPCR en las enfermedades neurodegenerativas de Parkinson y Alzheimer
Los receptores acoplados a proteína G o GPCRs conforman la mayor familia de receptores de membrana celular en organismos eucariotas. En humanos se han descrito más de 800 GPCRs, gran parte de ellos descubiertos mediante ...
Experimental and human studies on aging of adipose tissues: Role for Parkin
Brown and beige adipose tissues are mediators of adaptive energy expenditure in mammals, in contrast with the energy storage role of white fat. Mitochondrial activity, including uncoupled respiration, and the release of ...
Complejos del receptor sigma y de heterómeros de receptores acoplados a proteínas G en adicción y control de apetito
Actualmente, entre el 30-40% de los medicamentos comercializados tienen como diana a un receptor acoplado a proteína G (GPCR). Además, la capacidad que tienen estos receptores para interaccionar físicamente entre ellos y ...
Farmacologia Molecular dels Transportadors de Nucleòsids en Teràpia del Càncer: Nucleòsids Naturals No Canònics i Ruxolitinib
Nucleoside transporters are essential for nucleotide homeostasis as well as for nucleoside-derived drugs bioavailability. Non-canonical natural nucleosides or “epigenetic nucleosides” are endogenously produced and possess ...
Estudios de la interacción de los receptores de dopamina con otros receptores implicados en la enfermedad de Huntington
En la enfermedad de Huntington (HD), muchos síntomas están asociados con alteraciones en las funciones reguladas por la dopamina y el glutamato; una intervención directa sobre los receptores de dopamina D1 (D1R) pueden ...
The interplay of the adipokine neuregulin-4 on the inflammation, autophagy, oxidative stress and insulin responsiveness in adipocytes and skeletal muscle
Neuregulin-4 has emerged as a novel adipokine in recent years. Several authors have previously explored the endocrine role of this adipocyte-secreted growth factor in the liver metabolism. In those studies, it has been ...
Bariatric surgery and diet change in rats
An unbalanced, unhealthy diet is one of the main causes leading to obesity and the apparition of comorbidities. Bariatric surgery is currently the most effective and durable treatment against obesity. Despite being a ...
Nous factors implicats en la patologia cardíaca i l’obesitat
Cardiovascular diseases are one of the leading causes of mortality in industrialized countries and are caused by genetic factors, environmental factors or comorbidities. This thesis is focused on three cardiovascular risk ...
Study of the metabolic reprogramming associated to metastasis in colon cancer
Metastasis is the main cause of cancer-related deaths and it is of great biomedical importance to develop new therapeutic strategies that specifically target metastatic cells. Therefore, a better comprehension of the process ...
Implicació del miRNorma tumoral en l´expressió del transportador concentratiu de nucleòsids hCNT1
Human Concentrative Nucleoside Transporters (hCNTs) are encoded by SLC28 gene family. It has been demonstrated that hCNT1 is lost in some cancers. Furthermore, hCNTs have the ability of translocating selected nucleoside- ...
Lligams funcionals i bioquímics entre els transportadors de nucleòsids i el metabolisme de nucleòtids
Maintenance of balanced nucleotide pools is necessary for cellular homeostasis. The nucleotide content of the cell is determined by the uptake of nucleosides by specific transporters, the salvage pathway and de novo synthesis ...
Papel de la enterocina FGF15/19 en la plasticidad adiposa y cardíaca
[spa] El objetivo de la presente tesis se basa en establecer, mediante el uso de modelos experimentales animales y celulares, cuál es el papel de la enterocina FGF15/19: a) en la adiposidad y plasticidad de los ...
Definition and validation of targets associated with the metabolic reprogramming of haematological malignancies
Cancer cells, including leukemic cells, can react to therapeutic treatment by altering their metabolic phenotype (“metabolic reprogramming”) to keep their accelerated proliferative state, eventually becoming resistant to ...
Bioanalytical and proteomic approaches in the study of pathologic ECs dysfunctionality, oxidative stress and the effect of PFKFB3 modulators
The vascular endothelium is one of the major targets of oxidative stress, playing an important role in the development of vascular-related disorders, such as atherosclerotic disease1. Oxidative stress increases the formation ...
Metabolic adaptations in liver-specific OPA1 knockout mice
OPA1 is a dynamin-related protein that is responsible for the fusion of the internal mitochondrial membrane and essential to control the morphology of the mitochondrial cristae. Thus, it directly impacts the efficiency of ...
Oligomerización de receptores α₁ᴀ adrenérgicos y receptores dopaminérgicos en el SNC: implicación en la modulación de la atención
La atención es el proceso cognitivo básico que nos otorga la capacidad de seleccionar aquella información interna o externa que va a ser relevante para la toma de decisiones y el control del comportamiento. Múltiples ...
Biology of the cardiovascular Kv7.1 functional complex
Voltage gated K+ channels (Kv) are transmembrane proteins that allow the pass-thorugh of potassium ions, regulating the electrochemical gradient of the cell membrane. This way, they modulate several physiological processes, ...
Development of model-driven approaches for metabolic flux analysis and anticancer drug discovery
Metabolism is a hallmark of life and underlies most biological processes in both health and disease. For instance, dysregulation of liver metabolism underlies multifactorial disorders such as diabetes or obesity. Similarly, ...
