Àrea de contingut
Universitat de Barcelona
Visualitzant Departament de Biomedicina per títol
Ara mostrant els elements 1-20 de 57
Aberrant TIMP-1 regulation in tumor-associated fibroblasts by the TGF-β1/SMAD3 pathway in lung cancer: implications in tumor progression and resistance to antifibrotic therapies
Increased expression of TIMP-1 is associated with poor prognosis in virtually all cancer types, including lung cancer. However, how TIMP-1 is regulated in lung cancer and how it drives tumor progression is poorly defined. ...
Cerca i identificació de nous biomarcadors de fibrosi hepàtica per mitjà de tècniques proteòmiques
La detecció precoç de fibrosi hepàtica és de gran rellevància per al diagnòstic i el tractament dels pacients amb una malaltia hepàtica crònica. Actualment, s'utilitzen diversos procediments per a la seva estadificació. ...
Characterization of striatal development in Huntington’s Disease and its implication to the adult phenotype
[eng] Huntington's disease (HD) is a devastating neurodegenerative disorder that manifest itself through motor, cognitive and behavioral symptoms. HD is a monogenic disease caused by CAG expansion in the huntingtin gene, ...
Characterization of the in vivo immunomodulatory properties of CD5 and CD6
Our goal in this doctoral thesis was to study the immunomodulatory effects of CD5 and CD6, two proteins expressed on the lymphocytes membrane. These two proteins belong to the Scavenger Receptors Cystein- Rich superfamily, ...
Cholesterol and StARD1: a common nexus in Alcoholic Liver Injury and Niemann-Pick Type C disease-associated mitochondrial stress
[eng] Cholesterol accumulation in mitochondrial membranes is a common feature of various chronic diseases, such as cardiovascular disease, cancer, and Alzheimer's as well as liver diseases. Studies prior to this doctoral ...
Clasificación automática de malaria e inclusiones eritrocitarias anómalas en sangre periférica utilizando modelos de machine learning
[spa] Los especialistas de laboratorio juegan un papel esencial en el diagnóstico del paludismo mediante la identificación de características morfológicas cualitativas de los hematíes en la revisión del frotis de sangre ...
Comparative study of nanocarriers targeted to different transport pathways into and across the endothelium for brain delivery of therapeutic enzymes
[eng] The blood-brain barrier (BBB) is a major obstacle for the treatment of neurological diseases such as common Parkinson’s disease or rare lysosomal storage disorders (LSDs). LSDs are characterised by deficiency of ...
Depletion of aneuploid cells in epithelial tissues is shaped by cell-to-cell interactions
[eng] Aneuploidy, the major cause of miscarriages, is pervasive in early human embryos, and later in life, it correlates with pathological conditions including cancer and other ageing-related conditions. At the cellular ...
Development of an in vitro LTP-model of food anaphylaxis and study of mechanisms driving exacerbated responses
[eng] Mast cells (MCs), key immune system cells, can be activated via IgE or the MRGPRX2 receptor, releasing proinflammatory mediators that may trigger severe allergic reactions such as anaphylaxis. The study aims to better ...
Dual role of CDK5 on cognitive deficits and striatal vulnerability in Huntington’s disease
Huntington’s disease (HD) is a neurodegenerative disorder caused by an autosomic mutation on the Huntingtin (HTT) coding gene. HD is mainly characterized by the appearance of motor symptoms or choreas, which are associated ...
Effects of human serum albumin on TNFα-induced cell death and mitochondrial dysfunction in the liver cells
[eng] Albumin exerts pleiotropic actions beyond its oncotic power, which include binding, transport and detoxification of endogenous and exogenous molecules, antioxidant activity and the modulation of immune and inflammatory ...
El paper de p27 a la regulació de la via de Notch
Partint dels resultats previs obtinguts per aquest grup d’investigació, es planteja la següent hipòtesi de treball: “La proteïna p27 és un regulador de la via de Notch. Aquesta regulació es realitzaria, principalment, ...
Estimació del risc de neoplàsia colorectal avançada a partir de la quantificació de l’hemoglobina fecal en el cribratge del càncer de còlon i recte
INTRODUCCIÓ: A nivell mundial el càncer de còlon i recte (CCR) és el segon i el tercer en freqüència en homes i en dones, respectivament. La seva història natural és coneguda, se sap que habitualment es desenvolupa a ...
Evaluación funcional del péptido EAR-20 como posible agonista de los receptores ionotrópicos de glutamato de tipo NMDA
[spa] Debido a la importancia de la modulación del NMDAR, en el grupo de investigación de proteínas (GRIP) se han diseñado una serie de péptidos derivados de la Conantokina-G (Con-G), un péptido antagonista de los NMDARs, ...
Evaluation of therapeutic targets for the treatment of behavioral alterations and neuropathology in Huntington’s disease. The role of histone deacetylase 3 and p75 neurotrophin receptor
Huntington’s disease (HD) is a rare genetic disorder caused by an aberrant expansion of a CAG trinucleotide in the huntingtin gene (Htt). The neuropathology of the disease is characterized by progressive neuronal dysfunction ...
Exploring extracellular small RNAs as potential early biomarkers and mediators in the pathogenesis of Huntington’s disease
[eng] Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by an expansion of CAG triplets in the huntingtin gene (HTT). The main neuropathological signs of HD include the presence of ...
Funció de la MAPKAP quinasa Srkl en resposta a pertorbacions del citoesquelet d'actina en Schizosaccharomyces pombe
A Schizosaccharomyces pombe, la citocinesi està mediada per l’assemblatge i la constricció de l’anell contràctil d’actomiosiona. Pertorbacions petites en aquesta estructura activen un conjunt de mecanismes de control que ...
Illuminating cAMP signalling in neurodegenerative diseases: from synaptic plasticity mechanisms to therapeutic opportunities
[eng] With the ageing of the population, neurodegenerative diseases represent a growing public health problem, which could lead to an unsustainable social and economic burden if current trends persist. Surprisingly, most ...
Implications of astrocytic RTP801 in neuroinflammation and neurodegeneration in Alzheimer’s disease
[eng] The central nervous system (CNS), consisting of the brain and spinal cord, is supported by various cells including neurons, glial cells, and blood vessel cells. Neurons are responsible for transmitting signals, while ...
Inhibition of KRAS oncogenic activity by interfering with new KRAS interactors
[eng] INTRODUCTION: The Kirsten rat sarcoma oncogene (KRAS) homologue stands out as a prominent oncogene, distinguished by its notably elevated mutation rate compared to other oncogenes. This genetic anomaly is intricately ...
