Browsing Departament de Biomedicina by Title

Aberrant TIMP-1 regulation in tumor-associated fibroblasts by the TGF-β1/SMAD3 pathway in lung cancer: implications in tumor progression and resistance to antifibrotic therapies

Duch Gili, Paula (Date of defense: 2022-03-14)

Increased expression of TIMP-1 is associated with poor prognosis in virtually all cancer types, including lung cancer. However, how TIMP-1 is regulated in lung cancer and how it drives tumor progression is poorly defined. ...

Cerca i identificació de nous biomarcadors de fibrosi hepàtica per mitjà de tècniques proteòmiques

Marfà Bruix, Santiago (Date of defense: 2017-02-24)

La detecció precoç de fibrosi hepàtica és de gran rellevància per al diagnòstic i el tractament dels pacients amb una malaltia hepàtica crònica. Actualment, s'utilitzen diversos procediments per a la seva estadificació. ...

Characterization of the in vivo immunomodulatory properties of CD5 and CD6

Simões, Inês Tadeu dos Anjos (Date of defense: 2017-09-14)

Our goal in this doctoral thesis was to study the immunomodulatory effects of CD5 and CD6, two proteins expressed on the lymphocytes membrane. These two proteins belong to the Scavenger Receptors Cystein- Rich superfamily, ...

Cholesterol and StARD1: a common nexus in Alcoholic Liver Injury and Niemann-Pick Type C disease-associated mitochondrial stress

Solsona i Vilarrasa, Estel (Date of defense: 2021-03-22)

[eng] Cholesterol accumulation in mitochondrial membranes is a common feature of various chronic diseases, such as cardiovascular disease, cancer, and Alzheimer's as well as liver diseases. Studies prior to this doctoral ...

Comparative study of nanocarriers targeted to different transport pathways into and across the endothelium for brain delivery of therapeutic enzymes

Loeck, Maximilian (Date of defense: 2022-09-16)

[eng] The blood-brain barrier (BBB) is a major obstacle for the treatment of neurological diseases such as common Parkinson’s disease or rare lysosomal storage disorders (LSDs). LSDs are characterised by deficiency of ...

Dual role of CDK5 on cognitive deficits and striatal vulnerability in Huntington’s disease

Alvarez Periel, Elena (Date of defense: 2018-07-06)

Huntington’s disease (HD) is a neurodegenerative disorder caused by an autosomic mutation on the Huntingtin (HTT) coding gene. HD is mainly characterized by the appearance of motor symptoms or choreas, which are associated ...

Effects of human serum albumin on TNFα-induced cell death and mitochondrial dysfunction in the liver cells

Duran Güell, Marta (Date of defense: 2023-04-12)

[eng] Albumin exerts pleiotropic actions beyond its oncotic power, which include binding, transport and detoxification of endogenous and exogenous molecules, antioxidant activity and the modulation of immune and inflammatory ...

El paper de p27 a la regulació de la via de Notch

Durán Rodríguez, Rodrigo (Date of defense: 2022-01-28)

Partint dels resultats previs obtinguts per aquest grup d’investigació, es planteja la següent hipòtesi de treball: “La proteïna p27 és un regulador de la via de Notch. Aquesta regulació es realitzaria, principalment, ...

Estimació del risc de neoplàsia colorectal avançada a partir de la quantificació de l’hemoglobina fecal en el cribratge del càncer de còlon i recte

Augé Fradera, Josep Maria (Date of defense: 2017-05-26)

INTRODUCCIÓ: A nivell mundial el càncer de còlon i recte (CCR) és el segon i el tercer en freqüència en homes i en dones, respectivament. La seva història natural és coneguda, se sap que habitualment es desenvolupa a ...

Evaluación funcional del péptido EAR-20 como posible agonista de los receptores ionotrópicos de glutamato de tipo NMDA

García Díaz, Roberto (Date of defense: 2023-05-26)

[spa] Debido a la importancia de la modulación del NMDAR, en el grupo de investigación de proteínas (GRIP) se han diseñado una serie de péptidos derivados de la Conantokina-G (Con-G), un péptido antagonista de los NMDARs, ...

Evaluation of therapeutic targets for the treatment of behavioral alterations and neuropathology in Huntington’s disease. The role of histone deacetylase 3 and p75 neurotrophin receptor

Suelves Caballol, Núria (Date of defense: 2018-07-23)

Huntington’s disease (HD) is a rare genetic disorder caused by an aberrant expansion of a CAG trinucleotide in the huntingtin gene (Htt). The neuropathology of the disease is characterized by progressive neuronal dysfunction ...

Funció de la MAPKAP quinasa Srkl en resposta a pertorbacions del citoesquelet d'actina en Schizosaccharomyces pombe

Llanes Velasco, Julia (Date of defense: 2020-09-16)

A Schizosaccharomyces pombe, la citocinesi està mediada per l’assemblatge i la constricció de l’anell contràctil d’actomiosiona. Pertorbacions petites en aquesta estructura activen un conjunt de mecanismes de control que ...

Inhibition of KRAS oncogenic activity by interfering with new KRAS interactors

Abuasaker, Baraa (Date of defense: 2024-06-14)

[eng] INTRODUCTION: The Kirsten rat sarcoma oncogene (KRAS) homologue stands out as a prominent oncogene, distinguished by its notably elevated mutation rate compared to other oncogenes. This genetic anomaly is intricately ...

Involvement of Foxp2 in the alterations of the basal ganglia circuitry in Huntington’s Disease

Rodríguez Urgellés, Ened (Date of defense: 2022-01-20)

Huntington’s Disease (HD) is an autosomal dominant inherited neurodegenerative disorder characterized by motor, psychiatric, and cognitive manifestations. The disease is caused by an unstable expansion of the CAG trinucleotide ...

Machine Learning for predicting Immunotherapy response from routine Medical Imaging

Ligero Hernández, Marta (Date of defense: 2024-03-15)

[eng] HYPOTHESIS: Precision oncology has revolutionized the landscape of cancer treatment. Emerging therapeu- tic approaches, such as immunotherapy or anti-angiogenic agents, have exhibited remarkable outcomes in solid ...

Mecanismes neuronals de la picor aguda i crònica en neurones sensorials: implicació del canal TRESK

Andrés Bilbé, Alba (Date of defense: 2020-11-13)

[cat] TRESK (K2P18.1) és un canal de potassi de fuga que s’expressa en algunes subpoblacions de neurones sensorials, on modula el potencial de membrana en repòs, la descàrrega de potencial d’acció i l’excitabilitat neuronal. ...

Membrane Trafficking of TGF-β and Transcriptome Analysis in Marfan Syndrome

Siegert, Anna-Maria Elisa (Date of defense: 2017-10-20)

Marfan Syndrome (MFS) is a rare, autosomal dominant disorder of the connective tissue that affects between 1.5 and 17.2 in 100.000 live births. MFS is caused by mutations in the extracellular matrix (ECM) glycoprotein ...

Microphthalmia-associated Transcription Factor function and regulation in KIT oncogenic pathologies

Proaño Pérez, Elizabeth (Date of defense: 2022-11-30)

[eng] KIT (CD117) is a tyrosine kinase receptor expressed in hematopoietic progenitors, melanocytes, germ cells, mast cells, and interstitial cells of Cajal (ICC) of the digestive tract. KIT gain-of-function mutations have ...

Mitochondria and stem cell function: from somatic cells to iPSC-based disease modeling

Romero Moya, Damià (Date of defense: 2017-01-16)

Homeostasis of the hematopoietic stem/progenitor cell pool relies on a finely tuned balance between self-renewal, differentiation and proliferation. Recent work has revealed the importance of mitochondria during stem cell ...

Mitochondrial dynamics and quality control mechanisms in Huntington's disease

López Molina, Laura (Date of defense: 2022-06-17)

[spa] La enfermedad de Huntington (EH) es una enfermedad neurodegenerativa hereditaria causada por la mutación de la huntingtina (mHtt) que ocasiona síntomas motores, cognitivos y psiquiátricos. La característica ...