Mostrando ítems 1-10 de 10
Simões, Inês Tadeu dos Anjos (Fecha de defensa: 2017-09-14)
Our goal in this doctoral thesis was to study the immunomodulatory effects of CD5 and CD6, two proteins expressed on the lymphocytes membrane. These two proteins belong to the Scavenger Receptors Cystein- ...
Siegert, Anna-Maria Elisa (Fecha de defensa: 2017-10-20)
Marfan Syndrome (MFS) is a rare, autosomal dominant disorder of the connective tissue that affects between 1.5 and 17.2 in 100.000 live births. MFS is caused by mutations in the extracellular matrix ...
López Molina, Laura (Fecha de defensa: 2022-06-17)
[spa] La enfermedad de Huntington (EH) es una enfermedad neurodegenerativa hereditaria causada por la mutación de la huntingtina (mHtt) que ocasiona síntomas motores, cognitivos y psiquiátricos. La ...
Loeck, Maximilian (Fecha de defensa: 2022-09-16)
[eng] The blood-brain barrier (BBB) is a major obstacle for the treatment of neurological diseases such as common Parkinson’s disease or rare lysosomal storage disorders (LSDs). LSDs are characterised ...
Alvarez Periel, Elena (Fecha de defensa: 2018-07-06)
Huntington’s disease (HD) is a neurodegenerative disorder caused by an autosomic mutation on the Huntingtin (HTT) coding gene. HD is mainly characterized by the appearance of motor symptoms or choreas, ...
Morales Paytuví, Frederic (Fecha de defensa: 2022-02-04)
The following sections of the thesis are divided in two parts corresponding with the two projects conducted, whose objectives are stated below. 1. Caveolin in the endoplasmic reticulum During ...
Feu i Coll, Sònia (Fecha de defensa: 2019-03-28)
This thesis investigates the mechanisms that are activated in response to replication stress induced with hydroxyurea, an agent that causes deoxyribonucleotides depletion and arrest cells in S phase, ...
López Guimet, Júlia (Fecha de defensa: 2018-04-25)
The aorta is the main artery of the body, whose function is to collect the blood ejected by the heart and distribute it to all tissues. The elastic degree of the aortic wall necessary to withstand blood ...
Romero Moya, Damià (Fecha de defensa: 2017-01-16)
Homeostasis of the hematopoietic stem/progenitor cell pool relies on a finely tuned balance between self-renewal, differentiation and proliferation. Recent work has revealed the importance of mitochondria ...
Proaño Pérez, Elizabeth (Fecha de defensa: 2022-11-30)
[eng] KIT (CD117) is a tyrosine kinase receptor expressed in hematopoietic progenitors, melanocytes, germ cells, mast cells, and interstitial cells of Cajal (ICC) of the digestive tract. KIT gain-of-function ...