Now showing items 179-198 of 315

    Mediterranean cuisine and health: A multiapproach exploring the sofrito technique 

    Rinaldi de Alvarenga, José Fernando (Date of defense: 2019-07-18)

    Cooking made humans evolve. Cooking modified our gastrointestinal system, reducing the gut size and energy expenditure for digestion, which enabled the appearance of a more energy-dependent brain. Cooking process have ...

    Metabolic vulnerabilities of rhabdomyosarcoma: insights into the role of ASS1 

    Monaco, Paola (Date of defense: 2022-09-23)

    [eng] Rhabdomyosarcoma (RMS) is the most prevalent soft tissue sarcoma (STS) in children and adolescents. The Alveolar subtype (ARMS) is driven by PAX3-FOXO1, a fusion protein originated from a chromosomal translocation. ...

    Metabolismo de esteroles esterificados en plantas: implicación en el desarrollo y la respuesta a estrés 

    Burciaga Monge, Alma Delia (Date of defense: 2020-01-31)

    Los esteroles son una familia de compuestos triterpénicos que se presentan en forma libre o conjugada, como ésteres, glicósidos y acilglicósidos de esteroles. Cada especie vegetal tiene su propio perfil cualitativo y ...

    Metal-dependent 2-oxoacid aldolases as versatile biocatalysts for the synthesis of chiral multifunctional compounds 

    Marín-Valls, Roser (Date of defense: 2021-10-01)

    Biocatalysis gained importance in the latter half of the 20th century and its application in the pharmaceutical, food and chemical industries continues to expand nowadays. Enzymes catalyze chemical reactions in a highly ...

    Micro- and nanomaterials for drug delivery in skin diseases 

    Limón Magaña, David (Date of defense: 2017-07-21)

    anostructured supramolecular hydrogels and gold nanoparticles, as two kinds of nanomaterials, were synthsized, characterized and evaluated for their potential as drug delivery systems. Two bis-imidazolium cationic ...

    Microarray Strategies for Multiplexed Immunochemical Analysis 

    Guercetti, Julian (Date of defense: 2023-10-25)

    [eng] The current doctoral thesis titled “Microarray Strategies for Multiplexed Immunochemical Analysis” was carried out in the context of two research projects, expecting to develop multiplexed ligand-binding assays under ...

    Mitochondrial and cell cycle functions of SLIMP 

    Antolin Fontes, Albert (Date of defense: 2019-03-07)

    The mitochondrial Seryl-tRNA Synthetase (SerRS2) is a member of the class II tRNA synthetase family. The mature enzyme catalyses the ligation of serine to tRNASer in mitochondria. During the process of constructing a model ...

    Modular evolution of domain repeat proteins. Metal-binding and domain repeats of Metallothioneins in molluscs and chordates 

    Calatayud Robert, Sara (Date of defense: 2021-12-20)

    Proteins are composed of domains, a well-defined region within a protein that constitutes a stable, independently folding, compact structural unit, and that usually performs a specific function. During protein evolution, ...

    Molecular basis of p38a MAPK signaling 

    Gutierrez Prat, Núria (Date of defense: 2018-10-03)

    Cells often need to respond to damaging internal and external stimuli. One of the pathways that is frequently activated by stress stimuli involves activation of the kinase p38alpha, which can phosphorylate different ...

    Molecular mechanism of dBigH1 action 

    Tatarski, Miloš (Date of defense: 2018-09-21)

    INTRODUCTION: For decades it was known that many species contain embryo specific linker histone H1 variants that replace the somatic H1 during early embryogenesis. This is especially important because the early embryo ...

    Molecular segregation at multiple scales in perylene-based systems for the preparation advanced materials 

    Pérez Calm, Adrià (Date of defense: 2023-07-28)

    [eng] This thesis addresses molecular segregation in perylene-based systems, including lyotropic chromonic liquid crystals and water-in-water emulsions. These systems offer several advantages compared to conventional ...

    Molecular Self-Assembly for the preparation of novel nanostructured materials 

    Magaña Rodríguez, José Rodrigo (Date of defense: 2017-02-09)

    In this thesis, the phase behavior in water of a technical grade diglycerol-based surfactant (C41V) and a group of dyes (Quinaldine Red, Pyronin Y, N-Alkylthiacarbocyanines, Oxacarbocyanines, Pinacyanol and Alcian Blue) ...

    Monocapes autoassemblades electroactives: interaccions π-donador/π-acceptor per a induir transport en superfície 

    Giraldo Clemente, Sandra (Date of defense: 2021-02-26)

    Les proteïnes motores s’encarreguen del transport intracel·lular de cargoes a través de fibres tubulars presents en el citosquelet mitjançant la hidròlisis del trifosfat d'adenosina (ATP) com a força motriu del moviment. ...

    Nanopartículas y Células Dendríticas: Estudio de nuevas estrategias en inmunoterapia frente al VIH 

    Bargalló, Manel Enric (Date of defense: 2020-07-31)

    [spa] De entre las vacunas de ácidos nucleicos, las basadas en ARNm autoreplicativos (replicones) o ARNm convencionales unidos a diferentes nanopartículas (NPs) como: oro (Au-NP), nanocápsulas (NCs), ácido poliláctico ...

    Nanostructured systems for therapeutic treatment of neurodegenerative diseases = Sistemas nanoestructurados en el abordaje terapéutico de enfermedades neurodegenerativas 

    Sánchez-López, E. (Elena) (Date of defense: 2017-09-21)

    The incidence of neurodegenerative diseases, such as Alzheimer's disease, increases every year due to population aging. Therefore, the development of new therapeutic strategies, such as biodegradable nanostructured systems ...

    Nanostructured systems of thymol for dermatological and topical treatments 

    Folle, Camila (Date of defense: 2021-11-26)

    The skin is major organ of the human body, and its function is to protect the internal tissue from environmental changes, maintains the body temperature and avoid penetration of contaminants. Therefore, the skin barrier ...

    Nanotechnology-mediated strategies targeting cancer stem cells for advanced cancer treatment 

    Montero Martín, Sara (Date of defense: 2021-11-22)

    Despite the latest advances in early diagnosis and increased resources employed to develop new therapeutic options, effective control of cancer disease remains a challenge. In fact, cancer is the second leading cause of ...

    Neuroblastoma cancer stem cells: The role of NXPH1 and its receptor α-NRXN1 

    Fanlo Escudero, Lucía (Date of defense: 2019-12-18)

    Neuroblastoma (NB) is a devastating paediatric cancer that originates in the developing sympathetic nervous system. These tumours account for 40% of the cases of cancer diagnosed during the first year of life and 8% of the ...

    New antimicrobial strategies against bacterial infections 

    Baelo Álvarez, Aida (Date of defense: 2021-01-28)

    Bacterial infections are a major health concern worldwide due to the mortality and comorbidity associated levels. Besides the development of drug-resistance mechanisms, most recalcitrant infections are caused by bacteria ...

    New biotechnological systems for the research on aryltetralin lignans in Linum album 

    Lalaleo Córdova, Liliana Paulina (Date of defense: 2017-03-03)

    Linum album is an herbaceous plant with medical interest due to its content of podophyllotoxin (PTOX), an aryltetralin lignan with cytotoxic activity. The study of biotechnological alternatives has generated big interest. ...